International Journal of Clinical Oncology

, Volume 16, Issue 4, pp 328–334

Retrospective analysis of prognostic outcome of gastric cancer in young patients

  • Rieko Nakamura
  • Yoshiro Saikawa
  • Tsunehiro Takahashi
  • Hiroya Takeuchi
  • Humiki Asanuma
  • Yoshinori Yamada
  • Yuko Kitagawa
Original Article



It has been suggested that gastric cancer in young patients has a worse prognosis than in older patients, but this is controversial. This retrospective investigation was undertaken to understand the clinicopathological features and identify the prognostic factors of gastric cancer in young patients.


Patients included in this study were those treated and followed up for gastric cancer from 1989 to 2005. Operative records, clinical, pathological, and follow-up data were reviewed. The critical age cut-off value for obtaining distinctive prognoses was 34 years.


Of 1730 gastric cancer patients whose records were reviewed, 27 were less than 34 years old (YGC group). The YGC group contained significantly higher percentages of females, stage IV, macroscopic type 4 tumors, poorly differentiated histology, peritoneal dissemination, and epigastric pain symptoms than the gastric cancer group aged 34 years or more (OGC group). Survival in the YGC group was significantly worse than in the OGC group (p = 0.0363). Ten-year survival was 68.5% in the YGC group and 81.8% in the OGC group. Survival in the YGC group was poorer for the stage IV patients, compared with OGC patients, especially for the stage IV patients with peritoneal dissemination and without liver metastases (H0P1 patients) (p = 0.049).


Age in gastric cancer affects the prognosis, which in gastric cancer patients less than 34 years old was significantly poorer than for older patients, because of the high incidence of stage IV cancer with peritoneal dissemination in gastric cancer patients less than 34 years old.


Gastric cancer Young patients Prognosis 


  1. 1.
    Mitsudomi T, Matsusaka T, Wakasugi K et al (1989) A clinicopathological study of gastric cancer with special reference to age of the patients: an analysis of 1630 cases. World J Surg 13:225–230PubMedCrossRefGoogle Scholar
  2. 2.
    Fujimoto S, Takahashi M, Ohkubo H et al (1994) Comparative clinicopathological features of early gastric cancer in young and older patients. Surgery 115:516–520PubMedGoogle Scholar
  3. 3.
    Eguchi T, Takahashi Y, Yamagata M et al (1999) Gastric cancer in young patients. J Am Coll Surg 188:22–26PubMedCrossRefGoogle Scholar
  4. 4.
    Matley PJ, Dent DM, Madden MV et al (1988) Gastric carcinoma in young adults. Ann Surg 208:593–596PubMedCrossRefGoogle Scholar
  5. 5.
    Tso PL, Bringaze WL, Dauterive AH (1987) Gastric carcinoma in the young. Cancer 59:1362–1365PubMedCrossRefGoogle Scholar
  6. 6.
    Grabiec J, Owen DA (1985) Carcinoma of the stomach in younger persons. Cancer 56:388–396PubMedCrossRefGoogle Scholar
  7. 7.
    Holburt E, Freedman SI (1987) Gastric carcinoma in patients younger than 36 years. Cancer 60:1395–1399PubMedCrossRefGoogle Scholar
  8. 8.
    Bloss RS, Miller TA, Copeland EM (1980) Carcinoma of the stomach in the young adult. Surg Gynecol Obstet 150:883–886PubMedGoogle Scholar
  9. 9.
    Lai IR, Lee WJ, Chen CN et al (1997) Gastric cancer in the young. Hepatogastrectomy 44:1641–1645Google Scholar
  10. 10.
    Medina-Franco H, Melsin MJ, Cortes-Gonzales R (2000) Clinicopathological characteristics of gastric carcinoma in young and elderly patients: a comparative study. Ann Surg Oncol 7:515–519PubMedCrossRefGoogle Scholar
  11. 11.
    Kokkola A, Sipponen P (2000) Gastric carcinoma in young adults. Hepatogastroenterology 48:1552–1555Google Scholar
  12. 12.
    Koea JB, Karpeh MS, Brennan MF (2000) Gastric cancer in young patients: demographic, clinicopathological and prognostic factors in 92 patients. Ann Surg Oncol 7:346–351PubMedCrossRefGoogle Scholar
  13. 13.
    Kim DY, Ryu SY, Kim YJ et al (2003) Clinicopathological characteristics of gastric carcinoma in young patients. Langenbecks Arch Surg 388:245–249PubMedCrossRefGoogle Scholar
  14. 14.
    Santoro R, Carboni P, Lepiane P et al (2007) Clinicopathological features and prognosis of gastric cancer in European adults. Br J Surg 94:737–742PubMedCrossRefGoogle Scholar
  15. 15.
    Llanos O, Butte JM, Crovari F et al (2006) Survival of young patients after gastrectomy for gastric cancer. World J Surg 30:17–20PubMedCrossRefGoogle Scholar
  16. 16.
    Lauren P (1965) The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand 64:31–49PubMedGoogle Scholar
  17. 17.
    Antonioli DA, Goldman H (1982) Changes in the location and the type of gastric adenocarcinoma. Cancer 50:775–781PubMedCrossRefGoogle Scholar
  18. 18.
    Sipponen P, Jarvi O, Kekki M et al (1987) Decreased incidence of intestinal and diffuse types of gastric carcinoma in Finland during 20-years period. Scand J Gastroenterol 22:865–871PubMedCrossRefGoogle Scholar
  19. 19.
    Ramos-De la Medina A, Salgado-Nesme N et al (2004) Clinicopathologic characteristics of gastric cancer in a young patient population. J Gastrointest Surg 8(3):240–244PubMedCrossRefGoogle Scholar
  20. 20.
    Koea JB, Karpeh MS, Brennan MF (2000) Gastric cancer in young patients: demographic, clinicopathological, and prognostic factors in 92 patients. Ann Surg Oncol 7(5):346–351PubMedCrossRefGoogle Scholar
  21. 21.
    Nakamura T, Yao T, Niho Y et al (1999) A clinicopathological study in young patients with gastric carcinoma. J Surg Oncol 71(4):214–219PubMedCrossRefGoogle Scholar
  22. 22.
    Lo SS, Kuo HS, Wu CW et al (1999) Poorer prognosis in young patients with gastric cancer? Hepatogastroenterology 46(28):2690–2693PubMedGoogle Scholar
  23. 23.
    Wu MS, Chen CJ, Lin JT (2005) Host-environment interactions: their impact on progression from gastric inflammation to carcinogenesis and on development of new approaches to prevent and treat gastric cancer. Cancer Epidemiol Biomarkers Prev 14:1878–1882 (review)PubMedCrossRefGoogle Scholar
  24. 24.
    Oliveira C, Seruca R, Carneiro F (2006) Genetics, pathology, and clinics of familial gastric cancer. Int J Surg Pathol 14:21–33PubMedCrossRefGoogle Scholar

Copyright information

© Japan Society of Clinical Oncology 2011

Authors and Affiliations

  • Rieko Nakamura
    • 1
  • Yoshiro Saikawa
    • 1
  • Tsunehiro Takahashi
    • 1
  • Hiroya Takeuchi
    • 1
  • Humiki Asanuma
    • 2
  • Yoshinori Yamada
    • 2
  • Yuko Kitagawa
    • 1
  1. 1.Department of Surgery, School of MedicineKeio UniversityTokyoJapan
  2. 2.Department of SurgeryKitasato Institute HospitalTokyoJapan

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