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International Journal of Clinical Oncology

, Volume 16, Issue 5, pp 605–609 | Cite as

Weekly administration of temsirolimus for heavily pretreated patients with clear cell carcinoma of the ovary: a report of six cases

  • Masashi TakanoEmail author
  • Yoshihiro Kikuchi
  • Kazuya Kudoh
  • Tomoko Goto
  • Kenichi Furuya
  • Ryoko Kikuchi
  • Tsunekazu Kita
  • Keiichi Fujiwara
  • Tanri Shiozawa
  • Daisuke Aoki
Case Report

Abstract

Clear cell carcinoma (CCC) of the ovary is well-known to be chemotherapy resistant compared with other histologic subtypes. An inhibitor against the mammalian target of rapamycin, temsirolimus (TEM) has been reported to be effective in renal CCC. Therefore, we investigated the effects of TEM in patients with CCC of the ovary. Six patients with CCC of the ovary who had been heavily pretreated by more than 4 regimens were given TEM: the cycle consisted of weekly TEM (10 mg/m2) for 3 weeks followed by 1 week off. The treatment was continued until development of either progressive disease, or unmanageable adverse effects. Response evaluation was based upon the Response Evaluation Criteria in Solid Tumors version 1.0. Adverse effects were analyzed according to Common Terminology Criteria for Adverse Events version 3.0. The median cycle of weekly TEM was 3 (range 2–14). Among five cases in which responses could be evaluated, partial response was observed in one case (20%) and stabilized disease was seen in another case (20%). There were no toxicities greater than grade 3, and no case developed severe toxicity requiring discontinuation of weekly TEM. The patient who showed a partial response obtained a progression-free period of 14 months. In conclusion, weekly TEM shows a potential therapeutic benefit for patients with CCC of the ovary. Further studies including a translational approach are needed to select candidates for whom TEM therapy would be beneficial.

Keywords

Temsirolimus mTOR inhibitor Ovarian clear cell carcinoma Recurrence Refractory 

Notes

Conflict of interest

No author has any conflict of interest.

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Copyright information

© Japan Society of Clinical Oncology 2011

Authors and Affiliations

  • Masashi Takano
    • 1
    Email author
  • Yoshihiro Kikuchi
    • 2
  • Kazuya Kudoh
    • 3
  • Tomoko Goto
    • 1
  • Kenichi Furuya
    • 1
  • Ryoko Kikuchi
    • 4
  • Tsunekazu Kita
    • 5
  • Keiichi Fujiwara
    • 6
  • Tanri Shiozawa
    • 7
  • Daisuke Aoki
    • 8
  1. 1.Department of Obstetrics and GynecologyNational Defense Medical CollegeTokorozawaJapan
  2. 2.Department of GynecologyOhki Memorial Kikuchi Cancer Clinic for WomenTokorozawaJapan
  3. 3.Department of Obstetrics and GynecologyNishisaitama-chuo National HospitalTokorozawaJapan
  4. 4.Department of Basic PathologyNational Defense Medical CollegeTokorozawaJapan
  5. 5.Department of Obstetrics and GynecologyNara Prefectural Nara HospitalNaraJapan
  6. 6.Department of Gynecologic OncologySaitama Medical University International Medical CenterSaitamaJapan
  7. 7.Department of Obstetrics and GynecologyShinshu University School of MedicineMatsumotoJapan
  8. 8.Department of Obstetrics and GynecologyKeio University School of MedicineTokyoJapan

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