Risk factors for lower-limb lymphedema after surgery for cervical cancer
Lower-limb lymphedema (LLL) is a prevalent complication that is encountered after treatment for gynecological malignancies. The aim of this study was to evaluate the risk factors for postoperative LLL in patients with cervical cancer.
We conducted a retrospective chart review for patients who had undergone surgery, including systematic lymphadenectomy, for cervical cancer. Patients who died of cancer, were evaluated for short periods of time (<2 years), had missing medical records, or were suffering from deep venous thrombosis were excluded. We utilized the International Society of Lymphology staging of lymphedema severity as the diagnostic criteria for LLL, and patients with stage II or III lymphedema, as objectively determined by physicians, were included in the group of patients with LLL. Multivariate analysis was performed to confirm independent risk factors.
A total of 155 patients with cervical cancer were evaluated. Thirty-one patients (20.0%) contracted LLL with a median follow-up of 6.1 years. Suprafemoral node dissection (odds ratio, 9.5; 95% confidence interval, 1.2–73.3; P = 0.031) and adjuvant radiotherapy (3.7; 1.2–10.9; P = 0.019) were identified as independent risk factors.
Given that the effectiveness of the above two therapeutic options for cervical cancer is currently controversial, the clinical benefits of these therapies should be reevaluated specifically to conserve the quality of life for patients with this disease.
KeywordsCervical cancer Lower-limb lymphedema Surgery Risk factor
The authors thank Yusuke Ohba (Hokkaido University) for drafting the manuscript and Drs. M. Nakatani, Y. Suzuki, S. Minobe, and K. Okamoto (Hokkaido Cancer Center) for helpful discussion. This work was supported in part by grants from the Japan Society for the Promotion of Science (KAKENHI: 22591843, 22591844).
Conflict of interest
No author has any conflict of interest.
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