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International Journal of Clinical Oncology

, Volume 15, Issue 5, pp 489–492 | Cite as

A case of diaphragmatic clear cell carcinoma in a patient with a medical history of ovarian endometriosis

  • Koichi Fujiu
  • Hideaki Miyamoto
  • Satoshi Hashimoto
  • Nobuyasu Suzuki
  • Yoshinao Takano
  • Yasushi Teranishi
  • Hideo Sakuma
  • Hiroyuki Suzuki
Case Report

Abstract

We present a case of clear cell carcinoma located in the diaphragm in a patient with a medical history of ovarian endometriosis. Ultrasonography revealed the presence of a 2.5-cm nodule on the surface of the liver in a 65-year-old woman. She had undergone right salpingo-oophorectomy for treatment of an endometrial cyst of the right ovary at the age of 43 years and hysterectomy for treatment of a myoma of the uterus at the age of 51 years. We performed laparotomy and found that the tumor had originated from the diaphragm and invaded the liver. The diaphragm and liver were partially resected. Histopathological examination revealed the presence of clear cells and hobnail cells. The clear cells contained pale or eosinophilic cytoplasm and were arranged in a solid pattern. The hobnail cells lined the lumen and papillae. Immunohistochemical examination of the tumor cells showed positive staining for CK-7 and CA-125; negative staining for CK-20, TTF-1, and CA19-9; and weak positive staining for CEA. The findings were compatible with those of ovarian clear cell carcinoma. After 1 year, the patient had metastasis in the lung, and right lower lobectomy was performed.

Keywords

Clear cell carcinoma Diaphragm Endometriosis 

Notes

Conflict of interest statement

No author has any conflict of interest.

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Copyright information

© Japan Society of Clinical Oncology 2010

Authors and Affiliations

  • Koichi Fujiu
    • 1
  • Hideaki Miyamoto
    • 1
  • Satoshi Hashimoto
    • 2
  • Nobuyasu Suzuki
    • 3
  • Yoshinao Takano
    • 3
  • Yasushi Teranishi
    • 3
  • Hideo Sakuma
    • 4
  • Hiroyuki Suzuki
    • 5
  1. 1.Department of General Thoracic SurgerySouthern Tohoku General HospitalKoriyamaJapan
  2. 2.Department of Obstetrics and GynecologySouthern Tohoku General HospitalKoriyamaJapan
  3. 3.Department of SurgerySouthern Tohoku General HospitalKoriyamaJapan
  4. 4.Department of PathologySouthern Tohoku General HospitalKoriyamaJapan
  5. 5.Department of Surgery IFukushima Medical University School of MedicineFukushimaJapan

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