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Oxaliplatin-induced allergic reaction in patients with colorectal cancer in Japan

  • Yoshihiro Shibata
  • Hiroshi Ariyama
  • Eishi BabaEmail author
  • Yasushi Takii
  • Taito Esaki
  • Kenji Mitsugi
  • Tanji Tsuchiya
  • Hitoshi Kusaba
  • Koichi Akashi
  • Shuji Nakano
Original Article

Abstract

Background

Oxaliplatin is a platinum compound that is clinically effective for colorectal cancer (CRC), in combination with 5-fluorouracil (5-FU) and leucovorin (LV), and it is widely used for metastatic disease and for the adjuvant treatment of stage III CRC. With the increasing use of oxaliplatin in Japan, serious adverse events have been experienced other than hematologic and neurologic toxicities.

Methods

In order to clarify the clinical features of allergic reactions to oxaliplatin, we retrospectively investigated CRC patients who had received oxaliplatin-based chemotherapies.

Results

One hundred and twenty-five CRC patients who had been treated with FOLFOX regimens (containing oxaliplatin, 5-FU, and LV) were examined, and 21 patients (17%) were found to have developed allergic reactions. Sixteen patients (13%) had grade 1/2 adverse events, classified according to the common terminology criteria for adverse events (CTC-AE) version 3.0 and 5 (4%) had grade 3/4 adverse events. The allergic reaction appeared after a median number of nine cycles (range, 2–15 cycles). Previous chemotherapy included 5-FU/LV, CPT-11, and S-1. All of the patients with allergic reactions recovered completely when treated with antiallergy drugs. Oxaliplatin was reintroduced in 11 patients, with the use of prophylactic agents; allergic reaction to the reintroduction was not observed in 8 patients and grade 1/2 allergic reactions developed in 3 patients. No correlation was identified between allergic reaction and patients’ background characteristics such as sex, history of allergy, and profile of other adverse events.

Conclusion

Allergic reactions to oxaliplatin remain an important issue for patients being able to safely continue effective chemotherapies; further analysis will be needed to establish methods for the prediction and prophylaxis of such reactions.

Key words

Colorectal cancer Oxaliplatin Allergic reaction 

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Copyright information

© Japan Society of Clinical Oncology 2009

Authors and Affiliations

  • Yoshihiro Shibata
    • 1
  • Hiroshi Ariyama
    • 2
  • Eishi Baba
    • 1
    Email author
  • Yasushi Takii
    • 1
  • Taito Esaki
    • 2
  • Kenji Mitsugi
    • 3
  • Tanji Tsuchiya
    • 4
  • Hitoshi Kusaba
    • 1
  • Koichi Akashi
    • 1
  • Shuji Nakano
    • 1
  1. 1.Department of Medicine and Biosystemic ScienceKyushu University Graduate School of Medical SciencesFukuokaJapan
  2. 2.Department of Gastrointestinal and Medical OncologyNational Hospital Organization Kyushu Cancer CenterFukuokaJapan
  3. 3.Department of Medical OncologyHamanomachi HospitalFukuokaJapan
  4. 4.Department of Internal MedicineSawara HospitalFukuokaJapan

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