Factors correlated with peritoneal carcinomatosis and survival in patients with gastric cancer treated at a single institution in Brazil
- 106 Downloads
Gastric cancer is the second leading cause of death due to cancer worldwide and is particularly prevalent in Brazil. Promising new therapeutic agents have already shown activity in some gastrointestinal malignancies and their role in gastric cancer will need to be evaluated. Determining the prognostic factors of survival for patients with gastric cancer can help in identifying patients with a worse prognosis after treatment with the current chemotherapeutic regimens.
A retrospective chart review of 186 patients diagnosed with gastric cancer and treated at a single institution in Brazil from January 1994 to December 2004 was carried out. Univariate and multivariate analyses were performed to identify patient- and tumor-related characteristics associated with peritoneal metastasis at diagnosis and with overall survival.
Of the 186 patients, 76 were alive at the time of this analysis. The median survival for all patients was 30.1 months. Two independent factors associated with the presence of peritoneal metastasis at diagnosis were identified by multivariate analysis: signet-ring cell type (odds ratio [OR], 10.8; 95% confidence interval [CI], 3.1 to 37.5), and visceral metastasis (OR, 51.8; 95% CI, 12.4 to 215.4). The prognostic factors for poor survival were tumor stage T3 or T4 (hazard ratio [HR], 1.87; 95% CI, 1.09 to 3.22) and visceral metastasis (HR, 4.98; 95% CI, 3.02 to 8.20).
Two factors correlated with peritoneal metastasis and two prognostic factors for survival were identified. These findings may contribute to clinical decision-making, treatment tailoring, and the design of future trials.
Key wordsMultivariate analysis Neoplasm metastasis Peritoneum Prognosis Stomach neoplasms Survival analysis
Unable to display preview. Download preview PDF.
- 6.Curado MP, Edwards B, Shin HR, et al. (eds) (2007) Cancer incidence in five continents, vol. IX. IARC Scientific Publications No. 160, LyonGoogle Scholar
- 13.Anonymous (1993) A predictive model for aggressive non-Hodgkin’s lymphoma. The International Non-Hodgkin’s Lymphoma Prognostic Factors Project. N Engl J Med 329:987–994Google Scholar
- 20.Chau I, Norman AR, Cunningham D, et al. (2004) Multivariate prognostic factor analysis in locally advanced and metastatic esophago-gastric cancer-pooled analysis from three multicenter, randomized, controlled trials using individual patient data. J Clin Oncol 22:2395–2403PubMedCrossRefGoogle Scholar
- 24.American Joint Committee on Cancer AJCC Cancer staging manual, 6th edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
- 31.Lazo G, Yao JC, Najam AA, et al. (2002) Clinical risk factors for peritoneal metastases in esophagogastric junction carcinoma (GEJC). Proc Am Soc Clin Oncol 21; abstract 562Google Scholar