International Journal of Clinical Oncology

, Volume 14, Issue 4, pp 351–355 | Cite as

Large cell neuroendocrine carcinoma of the gallbladder: long survival achieved by multimodal treatment

  • Chigusa Shimono
  • Kazuhiro Suwa
  • Morio SatoEmail author
  • Shintaro Shirai
  • Katsuyuki Yamada
  • Yasushi Nakamura
  • Masatoshi Makuuchi
Case Report


Large cell neuroendocrine carcinoma of the gall-bladder is a rare disease in which the prognosis worsens with size. We report a case of large cell neuroendocrine carcinoma of the gallbladder in a 64-year-old woman who presented with a right upper quadrant mass whose longest diameter was 11.5 cm; the mass was initially considered to be unresectable because of probable invasion to the main portal vein and biliary tract. The patient received multi-modal treatment, consisting of intraarterial chemotherapy, three-dimensional radiation therapy, right trisegmentectomy, and γ-knife irradiation (for brain metastases). She has survived for 69 months since the initial diagnosis and has shown no signs of recurrence at 35 months after the last γ-knife irradiation for brain metastases. This result suggests that multimodal treatment including surgery, chemotherapy, and radiation therapy achieved a good response and led to long survival.

Key words

Large cell neuroendocrine carcinoma Gallbladder Chemotherapy Radiation therapy 


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Copyright information

© Japan Society of Clinical Oncology 2009

Authors and Affiliations

  • Chigusa Shimono
    • 1
  • Kazuhiro Suwa
    • 1
  • Morio Sato
    • 1
    Email author
  • Shintaro Shirai
    • 1
  • Katsuyuki Yamada
    • 1
  • Yasushi Nakamura
    • 2
  • Masatoshi Makuuchi
    • 3
  1. 1.Department of RadiologyWakayama Medical UniversityWakayamaJapan
  2. 2.Department of Clinical Laboratory MedicineWakayama Medical UniversityWakayamaJapan
  3. 3.Department of Surgery, Hepato-Biliary-Pancreatic Surgery DivisionTokyo UniversityTokyoJapan

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