Large cell neuroendocrine carcinoma of the gallbladder: long survival achieved by multimodal treatment
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Large cell neuroendocrine carcinoma of the gall-bladder is a rare disease in which the prognosis worsens with size. We report a case of large cell neuroendocrine carcinoma of the gallbladder in a 64-year-old woman who presented with a right upper quadrant mass whose longest diameter was 11.5 cm; the mass was initially considered to be unresectable because of probable invasion to the main portal vein and biliary tract. The patient received multi-modal treatment, consisting of intraarterial chemotherapy, three-dimensional radiation therapy, right trisegmentectomy, and γ-knife irradiation (for brain metastases). She has survived for 69 months since the initial diagnosis and has shown no signs of recurrence at 35 months after the last γ-knife irradiation for brain metastases. This result suggests that multimodal treatment including surgery, chemotherapy, and radiation therapy achieved a good response and led to long survival.
Key wordsLarge cell neuroendocrine carcinoma Gallbladder Chemotherapy Radiation therapy
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- 4.Capella C, Solcia, Sobin LH, Arnold R (2000) Endocrine tumours of the gall bladder and extrahepatic bile ducts. In: Hamilton SR, Aaltonen LA (eds) Pathology and genetics of tumours of the digestive system. World Health Organization Classification of Tumours. IARC, Lyon, pp 214–216Google Scholar