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International Journal of Clinical Oncology

, Volume 12, Issue 6, pp 408–415 | Cite as

Current status of intensity-modulated radiation therapy (IMRT)

  • Kazuo HatanoEmail author
  • Hitoshi Araki
  • Mitsuhiro Sakai
  • Takashi Kodama
  • Naoki Tohyama
  • Tohru Kawachi
  • Masaharu Imazeki
  • Takayuki Shimizu
  • Tsutomu Iwase
  • Minoru Shinozuka
  • Hideyo Ishigaki
REVIEW ARTICLE

Abstract

External-beam radiation therapy has been one of the treatment options for prostate cancer. The dose response has been observed for a dose range of 64.8–81 Gy. The problem of external-beam RT for prostate cancer is that as the dose increases, adverse effects also increase. Three-dimensional conformal radiation therapy (3D-CRT) has enabled us to treat patients with up to 72–76 Gy to the prostate, with a relatively acceptable risk of late rectal bleeding. Recently, intensity-modulated radiation therapy (IMRT) has been shown to deliver a higher dose to the target with acceptable low rates of rectal and bladder complications. The most important things to keep in mind when using an IMRT technique are that there is a significant trade-off between coverage of the target, avoidance of adjacent critical structures, and the inhomogeneity of the dose within the target. Lastly, even with IMRT, it should be kept in mind that a “perfect” plan that creates completely homogeneous coverage of the target volume and zero or small dose to the adjacent organs at risk is not always obtained. Participating in many treatment planning sessions and arranging the beams and beam weights create the best approach to the best IMRT plan.

Key words

Three-dimensional conformal radiation therapy (3D-CRT) Intensity-modulated radiation therapy (IMRT) Prostate cancer 

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Copyright information

© The Japan Society of Clinical Oncology 2007

Authors and Affiliations

  • Kazuo Hatano
    • 1
    Email author
  • Hitoshi Araki
    • 1
  • Mitsuhiro Sakai
    • 1
  • Takashi Kodama
    • 1
  • Naoki Tohyama
    • 1
  • Tohru Kawachi
    • 1
  • Masaharu Imazeki
    • 1
  • Takayuki Shimizu
    • 1
  • Tsutomu Iwase
    • 1
  • Minoru Shinozuka
    • 1
  • Hideyo Ishigaki
    • 1
  1. 1.Division of Radiation OncologyChiba Cancer CenterChibaJapan

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