International Journal of Clinical Oncology

, Volume 12, Issue 3, pp 231–233

Serum amylase is a sensitive tumor marker for amylase-producing small cell lung cancer?

  • Noriko Yanagitani
  • Kyoichi Kaira
  • Noriaki Sunaga
  • Yoichi Naito
  • Yoko Koike
  • Shinichi Ishihara
  • Tamotsu Ishizuka
  • Ryusei Saito
  • Masatomo Mori
CASE REPORT

Abstract

A 68-year-old male smoker was diagnosed as having amylase-producing small-cell lung cancer (SCLC). The serum amylase level was elevated, at 1756 IU/l, and the isozyme pattern was salivary type. Serum levels of “the tumor markers” CEA and NSE were 10.0 ng/ml and 22.6 ng/ml, respectively, but the level of pro-GRP was within the normal range. He was treated with combination chemotherapy of carboplatin and irinotecan. After completion of the chemotherapy, the serum amylase level decreased below the cutoff range and a computed tomography (CT) scan of the chest revealed marked reductions of the tumor in the primary site and in the lymph node metastasis. In November 2003, he was noted to have a slightly raised amylase level, of 168 IU/l, and raised levels of tumor markers. At this time, a CT scan, bone scintigraphy, and magnetic resonance imaging (MRI) of the brain demonstrated no recurrence. However, in December, MRI of the brain showed multiple metastases, and the recurrence of SCLC was thus confirmed. For the treatment of disease progression, the same regimen of chemotherapy as that given initially was administered. CT imaging revealed a partial response in the primary site and lymph node metastasis, and the serum amylase level decreased to 91 IU/l. After the completion of the second chemotherapy regimen, he underwent cranial irradiation and further chemotherapy. However, unfortunately, he died owing to deterioration of lung cancer. In this patient, the serum amylase level was found to be a highly sensitive marker of lung cancer.

Key words

Hyperamylasemia Small-cell lung cancer 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Weiss, MJ, Edmondson, HA, Wertman, M 1951Elevated serum amylase associated with bronchogenic carcinoma; report of caseAm J Clin Pathol2110571061PubMedGoogle Scholar
  2. 2.
    Minami, S, Komuta, K, Asai, M 2003A case of amylase-producing lung cancer (in Japanese)Nihon Kokyuki Gakkai Zasshi Kokyuu to Junkan41717721Google Scholar
  3. 3.
    Kitagawa, M, Nakagawa, M, Hosoda, S,  et al. 1993A case of amylase producing lung cancer (in Japanese)Kokyuu to Junkan41393396Google Scholar
  4. 4.
    Tsukawaki, M, Izawa, M, Yoshida, M,  et al. 1992A case of amylase-producing lung cancerIntern Med316063PubMedGoogle Scholar
  5. 5.
    Flood, JG, Schuerch, C, Dorazio, RC,  et al. 1976Marked hyperamylasemia associated with carcinoma of the lungClin Chem2412071212Google Scholar
  6. 6.
    Tomita, N, Matsuura, N, Horii, A,  et al. 1988Expression of alpha-amylase in human lung cancersCancer Res4832923296PubMedGoogle Scholar
  7. 7.
    Lenler-Petersen, P, Grove, A, Brock, A, Jelnes, R 1994Alpha-amylase in resectable lung cancerEur Respir J7941945PubMedGoogle Scholar
  8. 8.
    Uno, T, Mochizuki, H, Okada, T,  et al. 2003A case of amylase-producing lung cancer diagnosed by transbronchial curettageJpn J Lung Cancer43715719Google Scholar
  9. 9.
    Tomita, N, Matsuura, N, Horii, A,  et al. 1998Expression of alpha-amylase in human lung cancersCancer Res4832923296Google Scholar
  10. 10.
    Lenler-Petersen, P, Grove, A, Jelnes, R,  et al. 1994Alpha-amylase in resectable lung cancerEur Respir J7941945PubMedGoogle Scholar

Copyright information

© The Japan Society of Clinical Oncology 2007

Authors and Affiliations

  • Noriko Yanagitani
    • 1
  • Kyoichi Kaira
    • 1
  • Noriaki Sunaga
    • 1
  • Yoichi Naito
    • 1
  • Yoko Koike
    • 1
  • Shinichi Ishihara
    • 1
  • Tamotsu Ishizuka
    • 1
  • Ryusei Saito
    • 2
  • Masatomo Mori
    • 1
  1. 1.Department of Medicine and Molecular ScienceGunma University Graduate School of MedicineGunmaJapan
  2. 2.The National Nishigunma HospitalGunmaJapan

Personalised recommendations