International Journal of Clinical Oncology

, Volume 12, Issue 2, pp 120–124 | Cite as

Decrease of creatinine clearance rate with aging in patients with head and neck cancer in Japan

  • Goshi Nishimura
  • Mamoru Tsukuda
  • Choichi Horiuchi
  • Kenichi Satake
  • Takafumi Yoshida
  • Takahide Taguchi
  • Junichi Nagao
  • Mariko Kawakami
  • Norio Kondo
  • Hideki Matsuda
  • Yasukazu Mikami
ORIGINAL ARTICLE

Abstract

Background

We aimed to clarify the reason for the lower dosage of cis-platinum (CDDP) in patients with head and neck cancer in Japan compared with that in other countries, by evaluating renal function.

Methods

We studied 375 patients with head and neck cancer who had been hospitalized from January 1998 to October 2005, to evaluate and treat the disease. The creatinine clearance rate (Ccr) was calculated at least three times before beginning the treatments, and the average Ccr was estimated to evaluate the renal function.

Results

The Ccr decreased with aging, and the percentages of patients with Ccr lower than 65 ml/min per 1.73 m2 were 27.1% of patients in their fifties, 36.8% in their sixties, 62.3% in their seventies, and 87.5% in their eighties. There was no correlation between renal function and the Japanese lifestyle (i.e., diet. water consumption).

Conclusion

The renal function of Japanese decreases rapidly with aging, whereas that of Americans is maintained for longer periods. The poor renal function of Japanese is one of the causes of the need to reduce the dosage of or avoid the administration of CDDP in cancer patients.

Key words

Head and neck cancer Ccr CDDP 

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Copyright information

© The Japan Society of Clinical Oncology 2007

Authors and Affiliations

  • Goshi Nishimura
    • 1
  • Mamoru Tsukuda
    • 2
  • Choichi Horiuchi
    • 1
  • Kenichi Satake
    • 1
  • Takafumi Yoshida
    • 1
  • Takahide Taguchi
    • 1
  • Junichi Nagao
    • 1
  • Mariko Kawakami
    • 1
  • Norio Kondo
    • 1
  • Hideki Matsuda
    • 2
  • Yasukazu Mikami
    • 1
  1. 1.Department of OtorhinolaryngologyYokohama City University School of MedicineYokohamaJapan
  2. 2.Department of Biology and Function in the Head and NeckYokohama City University Graduate School of MedicineYokohamaJapan

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