International Journal of Clinical Oncology

, Volume 11, Issue 4, pp 320–325 | Cite as

Serial changes of international prostate symptom score following I-125 prostate brachytherapy

  • Toshio OhashiEmail author
  • Atsunori Yorozu
  • Kazuhito Toya
  • Shiro Saito
  • Tetsuo Momma



This study was conducted to assess serial changes in the International Prostate Symptom Score (IPSS) within the first 12 months after iodine-125 (I-125) prostate brachytherapy.


Between September 2003 and June 2004, a group of 103 patients with localized prostate cancer was treated with I-125 prostate brachytherapy, either alone (monotherapy; 60 patients) or in combination with external-beam radiotherapy (combined therapy; 43 patients). The IPSS was obtained at preimplant, and at 1, 6, and 12 months after treatment. The minimum IPSS follow-up for this study was 12 months. Dosimetry was based on computed tomography (CT) scan 1 month postimplant. Clinical, treatment-related, and dosimetric factors were assessed for correlations with the maximum IPSS increase (the peak IPSS minus the preimplant IPSS).


The median preimplant IPSS was 7.0, with a median peak of 16 at 1 month. The IPSS returned to baseline in 42 patients (40.8%) and it returned to within 3 points of the baseline in 64 (62.1%) at 1-year follow-up. On univariate and multivariate analyses, the maximum IPSS increase was best predicted by lower preimplant IPSS, in both the monotherapy and combined therapy groups.


In our series, IPSS after prostate brachytherapy peaked at 1 month and gradually returned to approximately baseline at 12 months.

Key words

Prostate cancer Brachytherapy Iodine-125 Urinary morbidity IPSS 


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Copyright information

© The Japan Society of Clinical Oncology 2006

Authors and Affiliations

  • Toshio Ohashi
    • 1
    Email author
  • Atsunori Yorozu
    • 1
  • Kazuhito Toya
    • 1
  • Shiro Saito
    • 2
  • Tetsuo Momma
    • 2
  1. 1.Department of RadiologyTokyo Medical Center, National Hospital Organization2-5-1 Higashigaoka, Meguro-kuTokyoJapan
  2. 2.Department of UrologyTokyo Medical Center, National Hospital OrganizationTokyoJapan

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