International Journal of Clinical Oncology

, Volume 10, Issue 5, pp 304–310 | Cite as

Treatment of lymphedema with lymphaticovenular anastomoses

  • Takashi Nagase
  • Koichi Gonda
  • Keita Inoue
  • Takuya Higashino
  • Norio Fukuda
  • Katsuya Gorai
  • Makoto Mihara
  • Misa Nakanishi
  • Isao KoshimaEmail author


Although lymphedema in the extremities is a troublesome adverse effect following radical resection of various cancers, conventional therapies for lymphedema are not always satisfactory, and new breakthroughs are anticipated. With the introduction of supermicrosurgical techniques for the anastomosis of blood or lymphatic vessels less than 0.8 mm in diameter, we have developed a novel method of lymphaticovenular anastomosis for the treatment of primary as well as secondary lymphedema in the extremities. Here, we review the pathophysiological aspects of lymphedema, emphasizing the importance of smooth-muscle cell function in the affected lymphatic walls. We then describe the theoretical basis and detailed operative techniques of our lymphaticovenular anastomoses. Although technically demanding, especially for beginners, we believe that this method will become a new clinical standard for the treatment of lymphedema in the near future.

Key words

Lymphedema Lymphaticovenular anastomosis Supermicrosurgery Lymphangiogenesis 


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Copyright information

© The Japan Society of Clinical Oncology 2005

Authors and Affiliations

  • Takashi Nagase
    • 1
  • Koichi Gonda
    • 1
  • Keita Inoue
    • 1
  • Takuya Higashino
    • 1
  • Norio Fukuda
    • 1
  • Katsuya Gorai
    • 1
  • Makoto Mihara
    • 1
  • Misa Nakanishi
    • 1
  • Isao Koshima
    • 1
    Email author
  1. 1.Department of Plastic and Reconstructive SurgeryUniversity of Tokyo Graduate School of MedicineTokyoJapan

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