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International Journal of Clinical Oncology

, Volume 8, Issue 4, pp 187–192 | Cite as

Translational and clinical studies of target-based cancer therapy

  • Nagahiro Saijo
  • Kazuto Nishio
  • Tomohide Tamura
REVIEW ARTICLE

Abstract

The increasing number of negative trials in cancer treatment has prompted a systematic re-evaluation of target-based drugs. It is our impression that the sensitivity of current clinical trial methodology is inadequate to demonstrate the effectiveness of target-based drugs, in terms of tumor shrinkage, delay in progression, or improved survival. Enrichment of sensitive populations, based on the data from translational studies, is essential for a better understanding of the role of novel therapies in cancer. Translational and clinical studies are key to the identification and maximization of benefit of target-based therapy

Key words

Target-based drug Translational study 

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Copyright information

© Springer-Verlag Tokyo 2003

Authors and Affiliations

  • Nagahiro Saijo
    • 1
  • Kazuto Nishio
    • 1
  • Tomohide Tamura
    • 1
  1. 1.National Cancer CenterTokyoJapan

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