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Post-operative morbidity ensuing surgery for insular gliomas: a systematic review and meta-analysis

  • Davide Tiziano Di CarloEmail author
  • Federico Cagnazzo
  • Yury Anania
  • Hugues Duffau
  • Nicola Benedetto
  • Riccardo Morganti
  • Paolo Perrini
Review
  • 7 Downloads

Abstract

The surgical resection of insular gliomas remains a challenge. Middle cerebral artery perforating arteries and deep functional pathways affect the extent of resection and the rate of post-operative morbidity. The authors performed a systematic review and meta-analysis of the literature examining early and permanent post-operative deficits in patients who underwent resection of insular gliomas using awake craniotomy with direct electrical stimulation (DES) versus surgery under general anesthesia. A systematic search of three databases was performed for studies published between 1990 and 2018. Random-effect meta-analysis was used to pool the rate of early and permanent post-operative deficits. Random-effect meta-regression was used to examine the association between the rate of post-operative deficit and the anesthesia protocol. We included eight studies evaluating 227 patients with insular glioma. The rate of permanent sequelae was lower after awake craniotomy with DES (3.5% vs 15.7%; P = .001), and early deficits were lower after surgery under general anesthesia (27.3% vs 47.7%; P = .04). Awake surgery was significantly more common among patients with tumor located within the dominant hemisphere (P < .001). No significant association arose between the rates of post-operative deficits and the use of intraoperative neuronavigation and the neurophysiological monitoring. Furthermore, neither extent of resection nor tumor histology influenced the onset of permanent sequelae. Awake craniotomy with DES is associated with a significantly lower rate of permanent neurological morbidity after an early increase of transient post-operative deficits. These data support the use of awake mapping in insular glioma resection.

Keywords

Insular glioma Awake surgery Insular surgery Meta-analysis 

Notes

Acknowledgments

We thank Ms. Juliet Strachan for English revision.

Funding

No funding was received for this research.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

This article does not contain any studies with human participants or animals performed by any of the authors.

Ethical approval

For this type of study, formal consent is not required.

Informed consent

The nature of this article did not require informed consent

Supplementary material

10143_2019_1113_MOESM1_ESM.pdf (173 kb)
ESM 1 (PDF 173 kb)
10143_2019_1113_MOESM2_ESM.pdf (246 kb)
ESM 2 (PDF 245 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NeurosurgeryAzienda Ospedaliero Universitaria Pisana (AOUP)PisaItaly
  2. 2.Department of Neurosurgery, Gui de Chauliac Hospital, CHU MontpellierMontpellier University Medical CenterMontpellierFrance
  3. 3.Institute for Neuroscience of Montpellier, INSERM U1051, Team “Plasticity of Central Nervous System, Human Stem Cells and Glial Tumors,” Saint Eloi HospitalMontpellier University Medical CenterMontpellierFrance
  4. 4.Department of Clinical and Experimental Medicine, Section of StatisticsUniversity of PisaPisaItaly

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