Gamma Knife radiosurgery for trigeminal neuralgia: when?

  • Alfio SpinaEmail author
  • Nicola Boari
  • Filippo Gagliardi
  • Michele Bailo
  • Sandro Iannaccone
  • Pietro Mortini
Letter to the editor

Dear Editor,

As widely known, classic trigeminal neuralgia (TN) represents one of the most common craniofacial pain syndromes [9, 15]. Medical therapy, as first-line treatment, is effective in controlling pain in a high percentage of cases at short-time period; however, this rate does significantly decrease over time [15]. Microvascular decompression (MVD) represents historically the reference technique [15].

Despite several other therapeutic options, almost half of the patients may experience pain recurrence, negatively affecting their quality of life (QoL) [2, 14, 15].

Stereotactic radiosurgery (SRS), such as Gamma Knife radiosurgery (GKRS), has increasingly become a popular treatment for TN, for the lack of treatment-related toxicity and mortality, less invasiveness, and good pain control rates [2, 14, 15, 16]. However, the right timing for GKRS or MVD is still a great matter of debate and data in literature are uneven [15]. Other SRS techniques, such as LINAC based SRS, namely,...


Trigeminal neuralgia Gamma Knife radiosurgery Microvascular decompression Craniofacial pain 


Compliance with ethical standard

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study, formal consent is not required.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Neurosurgery and Gamma Knife Radiosurgery, I.R.C.C.S. San Raffaele Scientific InstituteVita-Salute UniversityMilanItaly
  2. 2.Department of Rehabilitation and Functional Recovery, I.R.C.C.S San Raffaele Scientific InstituteVita-Salute UniversityMilanItaly

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