Clinical features, radiological findings, and treatment outcomes of high-grade lateral ventricular meningiomas: a report of 26 cases
- 245 Downloads
High-grade meningiomas in ventricles are rare, where most published series only include a few patients. A retrospective analysis was performed on the clinical features, radiological findings, and treatment outcomes of 26 patients with high-grade meningiomas in lateral ventricles who were surgically treated in our hospital between July 2008 and July 2016. A female predilection (female/male = 1.4:1) was observed with a mean age of 42.4 years. Headache and/or vomiting (65.3%) were the most common initial symptom, and with symptom duration time ranging between 7 days and 5 years (mean 8.5 months). The lateral ventricle trigone area was the most common site (80.7%). Twenty-two patients (84.6%) obtained gross total resection. The 2007 WHO classification was used to classify 22 (84.6%) meningiomas as grade II and the remaining four tumors were graded III. These tumors accounted for a recurrence rate of 38.5% (10 of 26 patients) and a mortality rate of 11.5% (3 deaths) during the follow-up periods. The recurrence rate after the gross total resection was 27.3% (6 of 22 patients). Radiotherapy was administered as an adjuvant treatment in 12 patients (46.2%) after surgery. There were 4 recurrences out of the 12 patients who received radiotherapy and 6 of the 14 patients relapsed without radiotherapy (p = 0.58). The subtotal resection was considered a risk factor for recurrence. The postoperative radiotherapy seemed to have little significance for the high-grade meningiomas in the lateral ventricles. Long-term follow-up is required, regardless of the resection grade, and reoperation is feasible for patients with recurrence.
KeywordsLateral ventricular meningioma High grade Radiotherapy Prognosis
The authors wish to thank all of the patients who trusted them and all the physicians and staff who helped with this study.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
For this type of study, formal consent is not required.
Informed consent was obtained from all individual participants included in the study.
- 1.Ostrom QT, Gittleman H, Liao P, Vecchione-Koval T, Wolinsky Y, Kruchko C, Barnholtz-Sloan JS (2017) CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2010-2014. Neuro-Oncology 19:v1–v88. https://doi.org/10.1093/neuonc/nox158 CrossRefGoogle Scholar
- 11.Pereira BJA, de Almeida AN, Paiva WS, de Aguiar PHP, Teixeira MJ, Marie SKN (2018) Natural history of intraventricular meningiomas: systematic review. Neurosurg Rev. https://doi.org/10.1007/s10143-018-1019-0
- 15.Grujicic D, Cavallo LM, Somma T, Illic R, Milicevic M, Raicevic S, Gazibara MS, Villa A, Savic D, Solari D, Cappabianca P (2017) Intraventricular meningiomas: a series of 42 patients at a single institution and literature review. World Neurosurg 97:178–188. https://doi.org/10.1016/j.wneu.2016.09.068 CrossRefGoogle Scholar
- 19.Majós C, Cucurella G, Aguilera C, Coll S, Pons LC (1999) Intraventricular meningiomas: MR imaging and MR spectroscopic findings in two cases. AJNR Am J Neuroradiol 20:882–885Google Scholar
- 23.Nanda A, Bir SC, Konar S, Maiti T, Kalakoti P, Jacobsohn JA, Guthikonda B (2016) Outcome of resection of WHO Grade II meningioma and correlation of pathological and radiological predictive factors for recurrence. J Clin Neurosci 31:112–121. https://doi.org/10.1016/j.jocn.2016.02.021 CrossRefGoogle Scholar
- 25.Aghi MK, Carter BS, Cosgrove GR, Ojemann RG, Aminhanjani S, Martuza RL, Jr CW, Nd BF (2009) Long-term recurrence rates of atypical meningiomas after gross total resection with or without postoperative adjuvant radiation. Neurosurgery 64:56–60. https://doi.org/10.1227/01.NEU.0000330399.55586.63 CrossRefGoogle Scholar
- 26.Stessin AM, Schwartz A, Judanin G, Pannullo SC, Boockvar JA, Schwartz TH, Stieg PE, Wernicke AG (2012) Does adjuvant external-beam radiotherapy improve outcomes for nonbenign meningiomas? A Surveillance, Epidemiology, and End Results (SEER)-based analysis. J Neurosurg 117:669–675. https://doi.org/10.3171/2012.7.JNS111439 CrossRefGoogle Scholar