Clinical features, radiological findings, and treatment outcomes of high-grade lateral ventricular meningiomas: a report of 26 cases

  • Yong Jiang
  • Liang Lv
  • Jiuhong Li
  • Weichao Ma
  • Cheng Chen
  • Peizhi Zhou
  • Shu JiangEmail author
Original Article


High-grade meningiomas in ventricles are rare, where most published series only include a few patients. A retrospective analysis was performed on the clinical features, radiological findings, and treatment outcomes of 26 patients with high-grade meningiomas in lateral ventricles who were surgically treated in our hospital between July 2008 and July 2016. A female predilection (female/male = 1.4:1) was observed with a mean age of 42.4 years. Headache and/or vomiting (65.3%) were the most common initial symptom, and with symptom duration time ranging between 7 days and 5 years (mean 8.5 months). The lateral ventricle trigone area was the most common site (80.7%). Twenty-two patients (84.6%) obtained gross total resection. The 2007 WHO classification was used to classify 22 (84.6%) meningiomas as grade II and the remaining four tumors were graded III. These tumors accounted for a recurrence rate of 38.5% (10 of 26 patients) and a mortality rate of 11.5% (3 deaths) during the follow-up periods. The recurrence rate after the gross total resection was 27.3% (6 of 22 patients). Radiotherapy was administered as an adjuvant treatment in 12 patients (46.2%) after surgery. There were 4 recurrences out of the 12 patients who received radiotherapy and 6 of the 14 patients relapsed without radiotherapy (p = 0.58). The subtotal resection was considered a risk factor for recurrence. The postoperative radiotherapy seemed to have little significance for the high-grade meningiomas in the lateral ventricles. Long-term follow-up is required, regardless of the resection grade, and reoperation is feasible for patients with recurrence.


Lateral ventricular meningioma High grade Radiotherapy Prognosis 



The authors wish to thank all of the patients who trusted them and all the physicians and staff who helped with this study.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

For this type of study, formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants included in the study.


  1. 1.
    Ostrom QT, Gittleman H, Liao P, Vecchione-Koval T, Wolinsky Y, Kruchko C, Barnholtz-Sloan JS (2017) CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2010-2014. Neuro-Oncology 19:v1–v88. CrossRefGoogle Scholar
  2. 2.
    Chen WC, Magill ST, Englot DJ, Baal JD, Wagle S, Rick JW, McDermott MW (2017) Factors associated with pre- and postoperative seizures in 1033 patients undergoing supratentorial meningioma resection. Neurosurgery 81:297–306. CrossRefGoogle Scholar
  3. 3.
    Odegaard KM, Helseth E, Meling TR (2013) Intraventricular meningiomas: a consecutive series of 22 patients and literature review. Neurosurg Rev 36:57–64; discussion 64. CrossRefGoogle Scholar
  4. 4.
    Kshettry VR, Ostrom QT, Kruchko C, Al-Mefty O, Barnett GH, Barnholtz-Sloan JS (2015) Descriptive epidemiology of World Health Organization grades II and III intracranial meningiomas in the United States. Neuro-Oncology 17:1166–1173. CrossRefGoogle Scholar
  5. 5.
    Wiemels J, Wrensch M, Claus EB (2010) Epidemiology and etiology of meningioma. J Neuro-Oncol 99:307–314. CrossRefGoogle Scholar
  6. 6.
    Li Z, Li H, Jiao Y, Ma J, Wang S, Cao Y, Zhao J (2018) Clinical features and long-term outcomes of pediatric intraventricular meningiomas: data from a single neurosurgical center. Neurosurg Rev 41:525–530. CrossRefGoogle Scholar
  7. 7.
    Bhatoe HS, Singh P, Dutta V (2006) Intraventricular meningiomas: a clinicopathological study and review. Neurosurg Focus 20:E9–E6. Google Scholar
  8. 8.
    Nayar VV, DeMonte F, Yoshor D, Blacklock JB, Sawaya R (2010) Surgical approaches to meningiomas of the lateral ventricles. Clin Neurol Neurosurg 112:400–405. CrossRefGoogle Scholar
  9. 9.
    Ma J, Cheng L, Wang G, Lin S (2014) Surgical management of meningioma of the trigone area of the lateral ventricle. World Neurosurg 82:757–769. CrossRefGoogle Scholar
  10. 10.
    Nanda A, Bir SC, Maiti T, Konar S (2016) Intraventricular meningioma: technical nuances in surgical management. World Neurosurg 88:526–537. CrossRefGoogle Scholar
  11. 11.
    Pereira BJA, de Almeida AN, Paiva WS, de Aguiar PHP, Teixeira MJ, Marie SKN (2018) Natural history of intraventricular meningiomas: systematic review. Neurosurg Rev.
  12. 12.
    Kim EY, Kim ST, Kim HJ, Jeon P, Kim KH, Byun HS (2009) Intraventricular meningiomas: radiological findings and clinical features in 12 patients. Clin Imaging 33:175–180. CrossRefGoogle Scholar
  13. 13.
    Liu M, Wei Y, Liu Y, Zhu S, Li X (2006) Intraventricular meningiomas: a report of 25 cases. Neurosurg Rev 29:36–40. CrossRefGoogle Scholar
  14. 14.
    Menon G, Nair S, Sudhir J, Rao R, Easwer HV, Krishnakumar K (2009) Meningiomas of the lateral ventricle - a report of 15 cases. Br J Neurosurg 23:297–303. CrossRefGoogle Scholar
  15. 15.
    Grujicic D, Cavallo LM, Somma T, Illic R, Milicevic M, Raicevic S, Gazibara MS, Villa A, Savic D, Solari D, Cappabianca P (2017) Intraventricular meningiomas: a series of 42 patients at a single institution and literature review. World Neurosurg 97:178–188. CrossRefGoogle Scholar
  16. 16.
    Gassel MM, Davies H (1961) Meningiomas in the lateral ventricles. Brain 84:605–627CrossRefGoogle Scholar
  17. 17.
    Bertalanffy A, Roessler K, Koperek O, Gelpi E, Prayer D, Neuner M, Knosp E (2006) Intraventricular meningiomas: a report of 16 cases. Neurosurg Rev 29:30–35. CrossRefGoogle Scholar
  18. 18.
    Jelinek J, Smirniotopoulos JG, Parisi JE, Kanzer M (1990) Lateral ventricular neoplasms of the brain: differential diagnosis based on clinical, CT, and MR findings. AJR Am J Roentgenol 155:365–372. CrossRefGoogle Scholar
  19. 19.
    Majós C, Cucurella G, Aguilera C, Coll S, Pons LC (1999) Intraventricular meningiomas: MR imaging and MR spectroscopic findings in two cases. AJNR Am J Neuroradiol 20:882–885Google Scholar
  20. 20.
    Vuckovic N, Kozic D, Vulekovic P, Vuckovic D, Ostojic J, Semnic R (2010) MR and MRS characteristics of intraventricular meningioma. J Neuroimaging 20:294–296. CrossRefGoogle Scholar
  21. 21.
    Lin BJ, Chou KC, Kao HW, Lin C, Tsai WC, Feng SW, Lee MS, Hueng DY (2014) Correlation between magnetic resonance imaging grading and pathological grading in meningioma. J Neurosurg 121:1201–1208. CrossRefGoogle Scholar
  22. 22.
    Iplikcioglu AC, Hatiboglu MA, Ozek E, Ozcan D (2014) Is progesterone receptor status really a prognostic factor for intracranial meningiomas? Clin Neurol Neurosurg 124:119–122. CrossRefGoogle Scholar
  23. 23.
    Nanda A, Bir SC, Konar S, Maiti T, Kalakoti P, Jacobsohn JA, Guthikonda B (2016) Outcome of resection of WHO Grade II meningioma and correlation of pathological and radiological predictive factors for recurrence. J Clin Neurosci 31:112–121. CrossRefGoogle Scholar
  24. 24.
    Champeaux C, Wilson E, Shieff C, Khan AA, Thorne L (2016) WHO grade II meningioma: a retrospective study for outcome and prognostic factor assessment. J Neuro-Oncol 129:337–345. CrossRefGoogle Scholar
  25. 25.
    Aghi MK, Carter BS, Cosgrove GR, Ojemann RG, Aminhanjani S, Martuza RL, Jr CW, Nd BF (2009) Long-term recurrence rates of atypical meningiomas after gross total resection with or without postoperative adjuvant radiation. Neurosurgery 64:56–60. CrossRefGoogle Scholar
  26. 26.
    Stessin AM, Schwartz A, Judanin G, Pannullo SC, Boockvar JA, Schwartz TH, Stieg PE, Wernicke AG (2012) Does adjuvant external-beam radiotherapy improve outcomes for nonbenign meningiomas? A Surveillance, Epidemiology, and End Results (SEER)-based analysis. J Neurosurg 117:669–675. CrossRefGoogle Scholar
  27. 27.
    Eom KS, Kim HS, Kim TY, Kim JM (2009) Intraventricular malignant meningioma with CSF-disseminated spinal metastasis: case report and literature review. J Korean Neurosurg Soc 45:256–259. CrossRefGoogle Scholar
  28. 28.
    Peh WC, Fan YW (1995) Case report: intraventricular meningioma with cerebellopontine angle and drop metastases. Br J Radiol 68:428–430. CrossRefGoogle Scholar
  29. 29.
    Kamiya K, Inagawa T, Nagasako R (1989) Malignant intraventricular meningioma with spinal metastasis through the cerebrospinal fluid. Surg Neurol 32:213–218CrossRefGoogle Scholar
  30. 30.
    Darwish B, Munro I, Boet R, Renaut P, Abdelaal AS, MacFarlane MR (2004) Intraventricular meningioma with drop metastases and subgaleal metastatic nodule. J Clin Neurosci 11:787–791. CrossRefGoogle Scholar
  31. 31.
    Shintaku M, Hashimoto K, Okamoto S-i (2007) Intraventricular meningioma with anaplastic transformation and metastasis via the cerebrospinal fluid. Neuropathology 27:448–452. CrossRefGoogle Scholar
  32. 32.
    Garcia-Conde M, Roldan-Delgado H, Martel-Barth-Hansen D, Manzano-Sanz C (2009) Anaplastic transformation of an atypical intraventricular meningioma with metastases to the liver: case report. Neurocirugia (Astur) 20:541–549CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NeurosurgeryWest China Hospital of Sichuan UniversityChengduChina

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