Neurosurgical Review

, Volume 42, Issue 2, pp 395–401 | Cite as

Olfactory function in patients after transsphenoidal surgery for pituitary adenomas—a short review

  • Martin Majovsky
  • Jaromir Astl
  • Daniel Kovar
  • Vaclav Masopust
  • Vladimir Benes
  • David NetukaEmail author
Short Review


Olfaction is an important sensory input that obviously affects many daily activities. However, olfactory dysfunction (hyposmia and anosmia) leads to a pronounced decrease in quality of life. Surprisingly, little attention has been paid to olfactory changes after transsphenoidal surgery for pituitary tumors. In this review, we summarize current knowledge of the effects of transsphenoidal pituitary surgery on olfaction and compare different surgical techniques. Based on selected studies, the endoscopic approach, in comparison with the microscopic approach, seems to be superior in terms of preservation of olfactory function, although the quality of data from these studies is generally poor. The best results were observed when the endoscopic approach was used without harvesting of the nasoseptal flap.


Olfaction Pituitary adenoma Transsphenoidal approach Endoscopic surgery Microscopic surgery Skull base 



This study is supported by 15-327 91A, MO 1012, Q25.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Ethical approval is not needed for this type of review.

Informed consent

Informed consent is not needed for this type of review.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Neurosurgery and Neurooncology, First Faculty of MedicineCharles University and Military University HospitalPragueCzech Republic
  2. 2.Department of Otorhinolaryngology and Maxillofacial Surgery, Third Faculty of MedicineCharles University and Military University HospitalPragueCzech Republic

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