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Neurosurgical Review

, Volume 37, Issue 2, pp 179–192 | Cite as

Current management of choroid plexus carcinomas

  • Matthew Z. Sun
  • Michael C. Oh
  • Michael E. Ivan
  • Gurvinder Kaur
  • Michael Safaee
  • Joseph M. Kim
  • Joanna J. Phillips
  • Kurtis I. Auguste
  • Andrew T. Parsa
Review

Abstract

Choroid plexus carcinoma (CPC) is a World Health Organization (WHO) grade III brain tumor with a poor prognosis that occurs mainly in children. Gross total resection of CPC is highly recommended and is associated with improved overall survival, although it is often associated with increased morbidity. The use of adjuvant therapies has yet to be standardized, although evidence suggests that for patients with incompletely resected CPCs, a combination of chemotherapy and radiation therapy may be beneficial. The use of radiation therapy for younger children (<3 years old) with CPC, however, is not recommended, due to the potential negative neurological sequelae associated with radiation to the developing brain. Given that the majority of CPC patients are young children, questions regarding optimal radiation dose, chemotherapy agents, and how to combine these two adjuvant treatment modalities to achieve the best outcomes remain unanswered. In this paper we summarize the current management of CPC in the literature. Further studies are needed to standardize the treatment paradigm for this malignant brain tumor.

Keywords

Choroid plexus carcinoma Radiation therapy Chemotherapy Surgery 

Notes

Acknowledgment

None.

Conflict of interest

The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

Funding

M.Z. Sun is a Howard Hughes Medical Institute medical research fellow. M. Safaee was supported by a grant from the Doris Duke Charitable Foundation. Dr. Oh received a National Research Service Award from the National Institutes of Health (F32NS073326-01). Dr. Ivan is funded by the National Research Education Foundation through the American Association of Neurological Surgeons. Dr. Parsa is partially funded by the Reza and Georgianna Khatib Endowed Chair in Skull Base Tumor Surgery.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Matthew Z. Sun
    • 1
  • Michael C. Oh
    • 1
  • Michael E. Ivan
    • 1
  • Gurvinder Kaur
    • 1
  • Michael Safaee
    • 1
  • Joseph M. Kim
    • 1
  • Joanna J. Phillips
    • 1
    • 2
  • Kurtis I. Auguste
    • 1
  • Andrew T. Parsa
    • 3
  1. 1.Department of Neurological SurgeryUniversity of California San FranciscoSan FranciscoUSA
  2. 2.Department of PathologyUniversity of California San FranciscoSan FranciscoUSA
  3. 3.Department of Neurological Surgery, Northwestern UniversityFeinberg School of MedicineChicagoUSA

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