Neurosurgical Review

, Volume 30, Issue 1, pp 22–31 | Cite as

Comparison between clipping and coiling on the incidence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis

  • Jean G. de OliveiraEmail author
  • Jürgen Beck
  • Christian Ulrich
  • Julian Rathert
  • Andreas Raabe
  • Volker Seifert


Cerebral vasospasm is one of the most important complications of aneurysmal subarachnoid hemorrhage. The effect of aneurysm occlusion technique on incidence of vasospasm is not exactly known. The objective was to analyze surgical clipping versus endovascular coiling on the incidence of cerebral vasospasm and its consequences. Using the MEDLINE PubMed (1966–present) database, all English-language manuscripts comparing patients treated by surgical clipping with patients treated by endovascular coiling, regarding vasospasm incidence after aneurysmal subarachnoid hemorrhage, were analyzed. Data extracted from eligible studies included the following outcome measures: incidence of total vasospasm, symptomatic vasospasm, ischemic infarct vasospasm-induced and delayed ischemic neurological deficit (DIND). A pooled estimate of the effect size was computed and the test of heterogeneity between studies was carried out using The Cochrane Collaboration’s Review Manager software, RevMan 4.2. Nine manuscripts that fulfilled the eligibility criteria were included and analyzed. The studies differed substantially with respect to design and methodological quality. The overall results showed no significant difference between clipping and coiling regarding to outcome measures. According to the available data, there is no significant difference between the types of technique used for aneurysm occlusion (clipping or coiling) on the risk of cerebral vasospasm development and its consequences.


Aneurysm Clipping Coiling Infarct Subarachnoid hemorrhage Vasospasm 



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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Jean G. de Oliveira
    • 1
    • 2
    Email author
  • Jürgen Beck
    • 1
  • Christian Ulrich
    • 1
  • Julian Rathert
    • 1
  • Andreas Raabe
    • 1
  • Volker Seifert
    • 1
  1. 1.Department of Neurosurgery, NeurocenterJohann Wolfgang Goethe UniversityFrankfurt am MainGermany
  2. 2.São Paulo-SPBrazil

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