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Neurosurgical Review

, Volume 29, Issue 1, pp 26–29 | Cite as

VEGF plasma levels in nonruptured intracranial aneurysms

  • I. Erol Sandalcioglu
  • Doreen Wende
  • Angelika Eggert
  • Jens P. Regel
  • Dietmar Stolke
  • Helmut Wiedemayer
Original Article

Abstract

Aneurysm growth appears to be associated with an increased risk of rupture. Therefore, it may be of interest to identify mechanisms contributing to aneurysm growth. Angiogenic factors, particularly vascular endothelial growth factor (VEGF), appear to play an important role in the pathogenesis and growth of cerebrovascular malformations. We aimed to study systemic VEGF levels as a potential systemic marker in patients with nonruptured intracranial aneurysms compared with healthy controls. Mean VEGF plasma concentrations were found to be increased in patients with nonruptured intracranial aneurysms compared with healthy controls (85.2 pg/ml versus 44.1 pg/ml). This difference did not reach significance in the analyzed study cohort (p=0.05) but only when the analysis was restricted to male patients (p=0.04). Female patients and controls demonstrated significantly increased VEGF plasma levels only on correlation with age but not with the presence of aneurysms. Neither the presence of multiple aneurysms nor aneurysm location were correlated with VEGF levels. Although overall VEGF plasma difference was not statistically significant, we found significantly increased levels in male patients. Furthermore, we identified a distinct group of female patients with intracranial aneurysms who presented excessively increased VEGF plasma levels to an amount that was not observed in the controls. Further studies may clarify the relationship of aneurysm growth and VEGF.

Keywords

Intracranial aneurysms Aneurysm growth VEGF Angiogenesis Growth factors 

Notes

Acknowledgements

This study was supported by grants of the IFORES program of the University Clinic of Essen (107-02080/IFORES). We are grateful to Dr. Alexander Schramm for his contribution to statistical analyses.

References

  1. 1.
    Akagawa H, Kasuya H, Onda H, Yoneyama T, Sasahara A, Kim CJ, Lee JC, Yang TK, Hori T, Inoue I (2005) Influence of endothelial nitric oxide synthase T-786C single nucleotide polymorphism on aneurysm size. J Neurosurg 102:68–71PubMedGoogle Scholar
  2. 2.
    Edelberg JM, Reed MJ (2003) Aging and angiogenesis. Front Biosci 8:1199–1209Google Scholar
  3. 3.
    Farnham JM, Camp NJ, Neuhausen SL, Tsuruda J, Parker D, MacDonald J, Cannon-Albright LA (2004) Confirmation of chromosome 7q11 locus for predisposition to intracranial aneurysm. Hum Genet 114:250–255CrossRefPubMedGoogle Scholar
  4. 4.
    Frosen J, Piippo A, Paetau A, Kangasniemi M, Niemela M, Hernesniemi J, Jaaskelainen J (2004) Remodeling of saccular cerebral artery aneurysm wall is associated with rupture: histological analysis of 24 unruptured and 42 ruptured cases. Stroke 35:2287–2293CrossRefPubMedGoogle Scholar
  5. 5.
    Futami K, Yamashita J, Tachibana O, Kida S, Higashi S, Ikeda K, Yamashima T (1995) Basic fibroblast growth factor may repair experimental cerebral aneurysms in rats. Stroke 26:1649–1654PubMedGoogle Scholar
  6. 6.
    Investigators ISoUIA (1998) Unruptured intracranial aneurysms–risk of rupture and risks of surgical intervention. N Engl J Med 339:1725–1733Google Scholar
  7. 7.
    Josko J (2003) Cerebral angiogenesis and expression of VEGF after subarachnoid hemorrhage (SAH) in rats. Brain Res 981:58–69CrossRefPubMedGoogle Scholar
  8. 8.
    Juvela S (2000) Risk factors for multiple intracranial aneurysms. Stroke 31:392–397PubMedGoogle Scholar
  9. 9.
    Juvela S, Poussa K, Porras M (2001) Factors affecting formation and growth of intracranial aneurysms: a long-term follow-up study. Stroke 32:485–491PubMedGoogle Scholar
  10. 10.
    Kataoka K, Taneda M, Asai T, Kinoshita A, Ito M, Kuroda R (1999) Structural fragility and inflammatory response of ruptured cerebral aneurysms. A comparative study between ruptured and unruptured cerebral aneurysms. Stroke 30:1396–1401PubMedGoogle Scholar
  11. 11.
    Koizumi T, Shiraishi T, Hagihara N, Tabuchi K, Hayashi T, Kawano T (2002) Expression of vascular endothelial growth factors and their receptors in and around intracranial arteriovenous malformations. Neurosurgery 50:117–124; discussion 124–6CrossRefPubMedGoogle Scholar
  12. 12.
    Krex D, Kotteck K, Konig IR, Ziegler A, Schackert HK, Schackert G (2004) Matrix metalloproteinase-9 coding sequence single-nucleotide polymorphisms in Caucasians with intracranial aneurysms. Neurosurgery 55:207–212; discussion 212–3CrossRefPubMedGoogle Scholar
  13. 13.
    Krex D, Rohl H, Konig IR, Ziegler A, Schackert HK, Schackert G (2003) Tissue inhibitor of metalloproteinases-1, -2, and -3 polymorphisms in a white population with intracranial aneurysms. Stroke 34:2817–2821CrossRefPubMedGoogle Scholar
  14. 14.
    Krex D, Schackert HK, Schackert G (2001) Genesis of cerebral aneurysms–an update. Acta Neurochir (Wien) 143:429–448; discussion 448–9CrossRefGoogle Scholar
  15. 15.
    Larsson A, Skoldenberg E, Ericson H (2002) Serum and plasma levels of FGF-2 and VEGF in healthy blood donors. Angiogenesis 5:107–110CrossRefPubMedGoogle Scholar
  16. 16.
    Malamitsi-Puchner A, Tziotis J, Tsonou A, Protonotariou E, Sarandakou A, Creatsas G (2000) Changes in serum levels of vascular endothelial growth factor in males and females throughout life. J Soc Gynecol Investig 7:309–312CrossRefPubMedGoogle Scholar
  17. 17.
    Nakajima N, Nagahiro S, Sano T, Satomi J, Satoh K (2000) Phenotypic modulation of smooth muscle cells in human cerebral aneurysmal walls. Acta Neuropathol (Berl) 100:475–480CrossRefGoogle Scholar
  18. 18.
    Shweiki D, Itin A, Soffer D, Keshet E (1992) Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843–845PubMedGoogle Scholar
  19. 19.
    Skirgaudas M, Awad IA, Kim J, Rothbart D, Criscuolo G (1996) Expression of angiogenesis factors and selected vascular wall matrix proteins in intracranial saccular aneurysms. Neurosurgery 39:537–545; discussion 545–7CrossRefPubMedGoogle Scholar
  20. 20.
    Sure U, Butz N, Schlegel J, Siegel AM, Wakat JP, Mennel HD, Bien S, Bertalanffy H (2001) Endothelial proliferation, neoangiogenesis, and potential de novo generation of cerebrovascular malformations. J Neurosurg 94:972–977PubMedGoogle Scholar
  21. 21.
    Yoneyama T, Kasuya H, Onda H, Akagawa H, Hashiguchi K, Nakajima T, Hori T, Inoue I (2004) Collagen type I alpha2 (COL1A2) is the susceptible gene for intracranial aneurysms. Stroke 35:443–448CrossRefPubMedGoogle Scholar
  22. 22.
    Zamani A (1997) MRA of intracranial aneurysms. Clin Neurosci 4:123–129PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • I. Erol Sandalcioglu
    • 1
  • Doreen Wende
    • 1
  • Angelika Eggert
    • 2
  • Jens P. Regel
    • 1
  • Dietmar Stolke
    • 1
  • Helmut Wiedemayer
    • 1
  1. 1.Department of NeurosurgeryUniversity Clinic of EssenEssenGermany
  2. 2.Division of Haematology/Oncology and EndocrinologyUniversity Children’s Hospital, University Clinic of EssenEssenGermany

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