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Functional & Integrative Genomics

, Volume 10, Issue 1, pp 11–19 | Cite as

Integrated gene networks in breast cancer development

  • Ivana RatkajEmail author
  • Emil Stajduhar
  • Srdan Vucinic
  • Sime Spaventi
  • Hrvojka Bosnjak
  • Kresimir Pavelic
  • Sandra Kraljevic Pavelic
Review

Abstract

Breast cancer is a complex and heterogenous disease. Classical molecular medical approaches cannot fully understand and comprehend its pathogenesis. In this review, the development of new biological markers for the early detection and creation of guided and specific therapy of breast cancer are discussed in light of the rapid advances in the “omics”. Results of cancer research in combination with large-scale methods that examine the expression status of genes and proteins have identified a large number of new biomarkers as well as confirmed the human growth hormone as an important player in the pathogenesis of this disease through its autocrine regulation where it influences the activation of Pax5 and HOXA1 gene networks.

Keywords

Breast cancer Proteomics Genomics hGH Pax5 HOXA1 Cancer profile 

Notes

Acknowledgments

We greatly appreciate the financial help of the Foundation of Croatian Academy of Sciences and Arts. This manuscript was also supported by the project of Ministry of Science Education and Sports 098-0982464-2393.

This work has been approved by an ethical committee of Clinical hospital “Sisters of Mercy” and all subjects gave informed consent.

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

10142_2010_159_MOESM1_ESM.doc (71 kb)
Supplementary material The immunohystochemical results showing the presence of hGH and RGH in epithelial and stromal compound of ductal invasive carcinoma and breast fibroadenoma. 0 absent, 1 weak reaction, 2 moderate reaction, 3 strong reaction (DOC 71 kb)

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Ivana Ratkaj
    • 1
    Email author
  • Emil Stajduhar
    • 2
  • Srdan Vucinic
    • 3
  • Sime Spaventi
    • 4
  • Hrvojka Bosnjak
    • 5
  • Kresimir Pavelic
    • 1
  • Sandra Kraljevic Pavelic
    • 1
  1. 1.Department of BiotechnologyUniversity of RijekaRijekaCroatia
  2. 2.Department of RadiologyClinical hospital “Sisters of mercy”ZagrebCroatia
  3. 3.Laboratory for Systems Biomedicine, Division of Molecular MedicineRuder Boskovic InstituteZagrebCroatia
  4. 4.Croatian Academy of Sciences and ArtsZagrebCroatia
  5. 5.Department of Internal MedicineClinical hospital “Sisters of mercy”ZagrebCroatia

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