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Marine Biotechnology

, Volume 14, Issue 3, pp 312–322 | Cite as

Algicidal Activity of Thiazolidinedione Derivatives Against Harmful Algal Blooming Species

  • Yeon-Mi Kim
  • Ying Wu
  • Thi Uyen Duong
  • Seul-Gi Jung
  • Si Wouk Kim
  • Hoon Cho
  • EonSeon Jin
Original Article

Abstract

Thiazolidinedione (TD) derivatives exhibit algicidal activity against harmful algal blooming species such as Chattonella marina, Heterosigma akashiwo, and Cochlodinium polykrikoides, as reported previously. In this study, the efficacies and selectivities of TD derivatives were tested by analyzing the structure–activity relationships of various TD derivatives. To investigate structure–activity relationships for growth inhibition of harmful algae, we added a methylene group between the cyclohexyl ring and oxygen of 5-(3-chloro-4-hydroxybenzylidene)-TD, which decreased the inhibitory potency of compound 17. Interestingly, another addition of a methylene group significantly increased the inhibitory potency against C. polykrikoides. The addition of 1 μM compound 17 resulted in the cell rupture of harmful algae after less than 10 h incubation at 20 °C. Compound 17 was applied to both harmful and non-harmful algae and showed a drastic reduction in the efficiency of photosystem II, resulting in reduced photosynthetic oxygen evolution. Compound 17 at a 5 μM concentration destroyed all of the harmful algae, while algicidal activity against non-harmful algae did not exceed 30% of the control within the concentration range tested. In contrast, a herbicide, 3-(3,4-dichlorophenyl)-1,1-dimethylurea, tested at a 5 μM concentration, exhibited 40–70% algicidal activity relative to that of the control against both harmful and non-harmful algae. Compound 17 is a promising lead compound for the development of algicides to control harmful algal blooming species.

Keywords

Harmful algal blooms Thiazolidinediones Algicides Photosynthetic inhibitor 

Notes

Acknowledgment

This work was supported by the Pioneer Research Program for Converging Technology of the Ministry of Education, Science and Technology, Republic of Korea (Grant No. M1071118001-08M1118-00110), and this work was partly supported by the National Research Foundation of Korea Grant funded by the Korean Government (MEST) (NRF-C1ABA001-2010-0020501).

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Dept. of Life Science and Research Institute for Natural SciencesHanyang UniversitySeoulSouth Korea
  2. 2.Dept. of Polymer Science & EngineeringChosun UniversityGwangjuSouth Korea
  3. 3.Dept. of Environmental EngineeringChosun UniversityGwangjuSouth Korea

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