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Marine Biotechnology

, Volume 9, Issue 4, pp 411–419 | Cite as

A Functional Approach to Transcriptome Profiling: Linking Gene Expression Patterns to Metabolites that Matter

  • Cindi A. Hoover
  • Marc Slattery
  • Adam G. Marsh
Invited Review

Abstract

Secondary metabolites or natural products have been isolated from many marine organisms. These metabolites often have important bioactive functions; however, very little information is available regarding the biosynthesis and regulation of many secondary metabolites. At a time when use of marine-derived metabolites is rapidly expanding in industry and pharmacological fields, a better understanding of the genetic mechanisms controlling secondary metabolite production is necessary. We review the recent development of a novel transcriptome profiling methodology that allows for rapid and high-throughput screening of changes in mRNA sequence pools. The application of genomics-based techniques and the integration of both biochemical and molecular data sets in marine organisms complement ongoing drug discovery efforts.

Keywords

gene expression genomics  secondary metabolite transcriptome 

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Cindi A. Hoover
    • 1
  • Marc Slattery
    • 2
  • Adam G. Marsh
    • 3
  1. 1.Molecular Biology Production GroupBroad Institute of MIT and HarvardCambridgeUSA
  2. 2.Department of PharmacognosyUniversity of MississippiUniversityUSA
  3. 3.College of Marine and Earth StudiesUniversity of DelawareLewesUSA

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