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Gastric Cancer

, Volume 22, Issue 1, pp 164–171 | Cite as

Outcomes of endoscopic submucosal dissection for gastric epithelial neoplasm in chronic kidney disease patients: propensity score-matched case–control analysis

  • Young Kwon Choi
  • Ji Yong AhnEmail author
  • Hee Kyong Na
  • Kee Wook Jung
  • Do Hoon Kim
  • Jeong Hoon Lee
  • Kee Don Choi
  • Ho June Song
  • Gin Hyug Lee
  • Hwoon-Yong Jung
Original Article
  • 155 Downloads

Abstract

Background

Little is known about the outcomes of gastric endoscopic submucosal dissection (ESD) in patients with chronic kidney disease (CKD). We compared the efficacy and safety of ESD between CKD and non-CKD patients.

Methods

From January 2005 to December 2014, 102 CKD patients underwent ESD for gastric neoplasms at a tertiary medical institution were reviewed retrospectively. A propensity score-matched control group (102 patients) was selected from non-CKD patients to compare clinical outcomes between CKD and non-CKD patients.

Results

En bloc resection (96.1%) and curative resection (88.2%) rates in the CKD group did not significantly differ from those in the non-CKD group. Median procedure times (25.0 vs. 21.5 min, p = 0.734) and perforation risk (p = 0.480) were similar between groups. The CKD group showed a tendency towards more bleeding events (p = 0.052) and had a significantly longer hospital stay (p = 0.001). In a subgroup analysis, stage 3 CKD patients exhibited a bleeding risk comparable to that exhibited by non-CKD patients (HR 1.35; 95% CI 0.36–5.06; p = 0.654), whereas stage 4 (HR 5.79; 95% CI 1.52–22.0; p = 0.010) and stage 5 (HR 4.80; 95% CI 1.58–14.6; p = 0.006) patients showed higher bleeding risks than non-CKD patients. In a multivariate analysis, stage 4/5 CKD was a significant predictor for bleeding risk (HR 4.99; 95% CI 1.32–18.8; p = 0.018).

Conclusions

ESD for gastric epithelial neoplasms can be performed in stage 3 CKD patients with comparable efficacy and safety to that performed in non-CKD patients. Stage 4 and 5 CKD patients should be closely monitored for bleeding events after ESD.

Keywords

Gastric neoplasms Endoscopic submucosal dissection Chronic kidney diseases 

Notes

Compliance with ethical standards

Conflict of interest

The authors have no potential conflict of interest relevant to the present study.

Ethical statement

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. The exemption from the informed consent requirement permitted by the Asan Medical Center Institutional Review Board.

Supplementary material

10120_2018_848_MOESM1_ESM.tif (651 kb)
Supplementary Figure 1. Distribution of calculated propensity score for overall enrolled patients. CKD: chronic kidney disease (TIF 651 KB)
10120_2018_848_MOESM2_ESM.docx (25 kb)
Supplementary Table 1. Baseline characteristics of the overall cohort (DOCX 24 KB)

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Copyright information

© The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2018

Authors and Affiliations

  • Young Kwon Choi
    • 1
  • Ji Yong Ahn
    • 1
    Email author
  • Hee Kyong Na
    • 1
  • Kee Wook Jung
    • 1
  • Do Hoon Kim
    • 1
  • Jeong Hoon Lee
    • 1
  • Kee Don Choi
    • 1
  • Ho June Song
    • 1
  • Gin Hyug Lee
    • 1
  • Hwoon-Yong Jung
    • 1
  1. 1.Department of Gastroenterology, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea

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