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Gastric Cancer

, Volume 13, Issue 4, pp 258–263 | Cite as

A Western single-center experience with endoscopic submucosal dissection for early gastrointestinal cancers

  • Sergio Coda
  • Paolo Trentino
  • Fabio Antonellis
  • Barbara Porowska
  • Francesco Gossetti
  • Franco Ruberto
  • Francesco Pugliese
  • Giulia d’Amati
  • Paolo Negro
  • Takuji Gotoda
Short Communication

Abstract

Endoscopic submucosal dissection (ESD) has gained worldwide acceptance as a treatment for early gastrointestinal cancers (EGICs). However, the management of these tumors in the Western world is still mainly surgical. Our aim was to evaluate the safety and feasibility of ESD at a European center. Based on the knowledge transferred by one of the most experienced Japanese institutions, we conducted a pilot study on 25 consecutive patients with EGICs located in the esophagus (n = 3), stomach (n = 7), duodenum (n = 1), and colon (n = 14) at our tertiary center over a 2-year-period. The main outcome measurements were complete (R0) resection, as well as en-bloc resection and the management of complications. The R0 and en-bloc resection rates were 100% and 84%, respectively. There were three cases of bleeding and five cases of perforation. With a median follow up of 18 months, two recurrences were observed. We conclude that ESD for early esophageal and gastric cancers is feasible and effective, while colonic ESD requires more expertise.

Key words

Gastrointestinal neoplasms Endoscopic submucosal dissection Endoscopic gastrointestinal surgery 

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Copyright information

© The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2010

Authors and Affiliations

  • Sergio Coda
    • 1
    • 2
  • Paolo Trentino
    • 1
  • Fabio Antonellis
    • 1
  • Barbara Porowska
    • 1
  • Francesco Gossetti
    • 3
  • Franco Ruberto
    • 4
  • Francesco Pugliese
    • 4
  • Giulia d’Amati
    • 5
  • Paolo Negro
    • 3
  • Takuji Gotoda
    • 6
  1. 1.Endoscopy Unit, Department of Surgery “Paride Stefanini,”University of Rome “La Sapienza,”RomeItaly
  2. 2.Department of Medicine, Division of Experimental MedicineImperial College LondonLondonUK
  3. 3.General Surgery Unit, Department of Surgery “Paride Stefanini,”University of Rome “La Sapienza,”RomeItaly
  4. 4.Critical Care Medicine and Pain Therapy, Department of AnesthesiologyUniversity of Rome “La Sapienza,”RomeItaly
  5. 5.Department of Experimental PathologyUniversity of Rome “La Sapienza,”RomeItaly
  6. 6.Department of EndoscopyNational Cancer Center HospitalTokyoJapan

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