Gastric Cancer

, 12:170 | Cite as

Metastatic gastric tumor from renal cell carcinoma

  • Daigo Yamamoto
  • Yoshinori Hamada
  • Satoshi Okazaki
  • Katsuhiro Kawakami
  • Seiichiro Kanzaki
  • Chizuko Yamamoto
  • Mitsuo Yamamoto
Case Report


Metastatic tumors of the stomach are rare, with an incidence of 0.2%–0.7%, and they have been reported to result mainly from primary breast cancers, lung cancers, and melanoma. Further, among such metastatic tumors, the metastasis of renal cell carcinoma (RCC) to the stomach is an extremely rare disease, and it is usually reported in autopsy series. We report a rare case of metastatic gastric tumor derived from right renal carcinoma. Gastric endoscopy confirmed a large, polypoid, friable mass (type 1 tumor, about 7 cm in diameter) in the middle part of the stomach body. The mass was surgically excised and pathological examination showed that the gastric tumor was derived from a metastasis from the right kidney, because it was composed of malignant cells that were identical to those from the removed RCC. In addition, the tumor cells were immunoreactive for CD10, CD15, Ecadherin, early membrane antigen (EMA), and vimentin, but no reactivity was observed for cytokeratins 7 and 20 or c-KIT. Although gastric metastatic tumor derived from renal carcinoma is rare, the precise pre- and postoperative diagnosis may be important; thus, investigation for such metastatic tumors should be performed routinely in the follow up of patients who have been treated for RCC.

Key words

Renal cell carcinoma Metastasis Stomach 


  1. 1.
    Riviello C, Tanini I, Cipriani G, Pantaleo P, Nozzoli C, Poma A, et al. Unusual gastric and pancreatic metastatic renal cell carcinoma presentation 10 years after surgery and immunotherapy: a case report and a review of literature. World J Gastroenterol 2006;28:5234–5236.Google Scholar
  2. 2.
    Green LK. Hematogenous metastasis to the stomach. A review of 67 cases. Cancer 1990;65:1596–1600.CrossRefPubMedGoogle Scholar
  3. 3.
    Ming S. Tumors of the esophagus and stomach. In: Atlas of tumor pathology, 2nd series, part 7. Bethesda: Armed Forces Institute of Pathology; 1973. p. 253–255.Google Scholar
  4. 4.
    Odori T, Tsuboi Y, Katoh K, Yamamda K, Morita K, Ohara A, et al. A solitary hematogenous metastasis to the gastric wall from renal cell carcinoma 4 years after radical nephrectomy. J Clin Gastroenterol 1998;26:153–154.CrossRefPubMedGoogle Scholar
  5. 5.
    Tolia BM, Whitemore WF. Solitary metastasis from renal cell carcinoma. J Urol 1975;114:836–838.PubMedGoogle Scholar
  6. 6.
    Campoli PM, Ejima FH, Cardoso DM. Metastatic cancer to the stomach. Gastric Cancer 2006;9:19–25.CrossRefPubMedGoogle Scholar
  7. 7.
    Picchio M, Paioletti A, Santini E, Iacoponi S, Cordahi M. Gastric metastasis from renal cell carcinoma 14 years after radical nephrectomy. Acta Chir Belg 2000;100:228–230.PubMedGoogle Scholar
  8. 8.
    Menuck LS, Amberg JR. Metastatic disease involving the stomach. Am J Dig Dis 1975;20:903–913.CrossRefPubMedGoogle Scholar
  9. 9.
    Green LK. Hematogenous metastases to the stomach. A review of 67 cases. Cancer 1990;65:1596–1600.CrossRefPubMedGoogle Scholar
  10. 10.
    Oda I, Kondo H, Yamao T. Metastatic tumors to the stomach: analysis of 54 patients diagnosed at endoscopy and 347 autopsy cases. Endoscopy 2001;33:507–510.CrossRefPubMedGoogle Scholar
  11. 11.
    Iwanaga T, Iwasaki Y, Arai K, Nunobe S, Iwagami S, Takahasi K. Gastric metastasis from renal cell carcinoma 2 years after radical nephrectomy: report of a case. Jpn J Clin Surg 2007;68:1432–1436.CrossRefGoogle Scholar
  12. 12.
    Saidi RF, Remine SG. Isolated gastric metastasis from renal cell carcinoma 10 years after radical nephrectomy. J Gastroenterol Hepatol 2007;22:143–144.CrossRefPubMedGoogle Scholar
  13. 13.
    Pollheimer MJ, Hinterleitner TA, Pollheimer VS, Schlemmer A, Langner C. Renal cell carcinoma metastatic to the stomach: single-centre experience and literature review. BJU Int 2008;102:315–319.CrossRefPubMedGoogle Scholar
  14. 14.
    Avery AK, Beckstead J, Renshaw AA, Corless CL. Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasms. Am J Surg Pathol 2000;24:203–210.CrossRefPubMedGoogle Scholar
  15. 15.
    Droz D, Zachar D, Charbit L, Gogusev J, Chretein Y, Iris L. Expression of the human nephron differentiation molecules in renal cell carcinomas. Am J Pathol 1990;137:895–905.PubMedGoogle Scholar
  16. 16.
    Chu PG, Weiss LM. Keratin expression in human tissues and neoplasms. Histopathology 2002;40:403–439.CrossRefPubMedGoogle Scholar

Copyright information

© The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2009

Authors and Affiliations

  • Daigo Yamamoto
    • 1
    • 2
  • Yoshinori Hamada
    • 1
  • Satoshi Okazaki
    • 1
  • Katsuhiro Kawakami
    • 3
  • Seiichiro Kanzaki
    • 4
  • Chizuko Yamamoto
    • 4
  • Mitsuo Yamamoto
    • 2
  1. 1.Department of SurgeryKansai Medical University Hirakata HospitalHirakata, OsakaJapan
  2. 2.Department of SurgerySeiko HospitalNeyagawa, OsakaJapan
  3. 3.Department of NeurosurgerySeiko HospitalNeyagawa, OsakaJapan
  4. 4.Department of Internal MedicineSeiko HospitalNeyagawa, OsakaJapan

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