Gastric Cancer

, Volume 10, Issue 2, pp 104–111

Docetaxel and oxaliplatin combination in second-line treatment of patients with advanced gastric cancer

  • Carlo Barone
  • Michele Basso
  • Giovanni Schinzari
  • Carmelo Pozzo
  • Nunziatina Trigila
  • Ettore D'Argento
  • Michela Quirino
  • Antonio Astone
  • Alessandra Cassano
Original article

DOI: 10.1007/s10120-007-0415-x

Cite this article as:
Barone, C., Basso, M., Schinzari, G. et al. Gastric Cancer (2007) 10: 104. doi:10.1007/s10120-007-0415-x

Abstract

Background

In advanced gastric cancer few data are available on the efficacy or safety of new drug combination regimens after progression following first-line chemotherapy.

Methods

Patients with histologically confirmed advanced gastric cancer and Eastern Cooperative Oncology Group (ECOG) performance status (PS) less than 2, progressing after first-line chemotherapy, were eligible. Patients were treated with docetaxel 75 mg/m2 on day 1 and oxaliplatin 80 mg/m2 on day 2, every 3 weeks, until progression or unacceptable toxicity.

Results

Between May 2002 and April 2005, 38 patients were enrolled. Men accounted for 73.7% of the patients and the median age was 59 years. The primary tumor was not resected in 47.4% of the patients; the peritoneum was the most frequent metastatic site (60.5%). The first-line treatment was cisplatin, epirubicin, and infusional 5-fluorouracil (ECF) in 81.5% of the patients and cisplatin and infusional 5-fluorouracil (CF) in 15.7%. The median number of cycles was 4.3. The treatment was well tolerated, with no toxic deaths. National Cancer Institute (NCI) grade III-IV neutropenia was frequent (26.3%), but no febrile neutropenia was reported. Severe asthenia (15.7%) and severe nausea (15.7%) required dose reductions in 2 patients and treatment discontinuation in another. The overall response rate was 10.5%, and 18 patients (47.3%) experienced disease stabilization (7 of them with significant clinical benefit). Median time to progression was 4.0 months (range, 2–8 months) and median overall survival was 8.1 months (range, 3–26 months). Thirteen patients (34.2%) also received third-line chemotherapy, with an irinotecan-containing regimen, and their median overall survival was higher than that of the other patients (16.3 vs 6.0 months)

Conclusion

The combination of oxaliplatin and docetaxel shows only marginal activity as second-line treatment, but it has a good tolerability profile. This suggests that there is room for optimizing the schedule as well as for planning sequential treatments in gastric cancer.

Key words

Oxaliplatin Docetaxel Gastric cancer Second-line therapy 

Copyright information

© International and Japanese Gastric Cancer Association 2007

Authors and Affiliations

  • Carlo Barone
    • 1
  • Michele Basso
    • 1
  • Giovanni Schinzari
    • 1
  • Carmelo Pozzo
    • 1
  • Nunziatina Trigila
    • 1
  • Ettore D'Argento
    • 1
  • Michela Quirino
    • 1
  • Antonio Astone
    • 1
  • Alessandra Cassano
    • 1
  1. 1.Department of Medical OncologyUniversità Cattolica del Sacro CuoreRomaItaly

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