Gastric Cancer

, Volume 7, Issue 2, pp 78–84

Expression of Mcl-1 and p53 proteins predicts the survival of patients with T3 gastric carcinoma

  • Yoshihiko Maeta
  • Shunichi Tsujitani
  • Sachiko Matsumoto
  • Kenichi Yamaguchi
  • Shigeru Tatebe
  • Akira Kondo
  • Masahide Ikeguchi
  • Nobuaki Kaibara
Original article

DOI: 10.1007/s10120-004-0272-9

Cite this article as:
Maeta, Y., Tsujitani, S., Matsumoto, S. et al. Gastric Cancer (2004) 7: 78. doi:10.1007/s10120-004-0272-9

Abstract

Background

The expression of myeloid cell leukemia 1 (Mcl-1) and p53 proteins was investigated for clinicopathological and prognostic significance in patients with gastric carcinoma.

Methods

Mcl-1 protein was immunohistochemically examined in 182 patients with gastric carcinoma. The overexpression of p53 was also analyzed in T3 gastric carcinomas.

Results

The expression of Mcl-1 was detected in 127 (69.8%) patients with gastric carcinoma. Mcl-1 was detected significantly more frequently in the undifferentiated type (P ≪ 0.05) and in the advanced stage of disease (P ≪ 0.05). The prognosis of patients with an Mcl-1-positive tumor was significantly worse than that of those with an Mcl-1-negative tumor (P ≪ 0.05). Multivariate analysis revealed that the expression of Mcl-1 was an independent prognostic factor, as were lymph node metastasis and tumor size. There was no significant relationship between the expression of Mcl-1 and p53. In patients with T3 gastric carcinoma who underwent curative surgery; however, Mcl-1(−)/p53 (−) tumor demonstrated the best postoperative survival rate, whereas Mcl-1(+)/p53(+) tumor had the worst.

Conclusion

The expression of Mcl-1 is an indicator of tumor progression and postoperative recurrence in patients with gastric carcinoma. Combined analysis of Mcl-1 and p53 proteins may accurately predict the survival of patients with T3 gastric carcinoma.

Key words

Gastric cancer Mcl-1 p53 Immunohistoche-mistry Survival 

Copyright information

© Springer-Verlag Tokyo 2004

Authors and Affiliations

  • Yoshihiko Maeta
    • 1
  • Shunichi Tsujitani
    • 1
  • Sachiko Matsumoto
    • 1
  • Kenichi Yamaguchi
    • 1
  • Shigeru Tatebe
    • 1
  • Akira Kondo
    • 1
  • Masahide Ikeguchi
    • 1
  • Nobuaki Kaibara
    • 1
  1. 1.Department of Surgery, Faculty of MedicineTottori UniversityYonagoJapan

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