Gastric Cancer

, Volume 5, Supplement 1, pp 5–11 | Cite as

The epidemiology of gastric cancer

  • David M. Roder
Article

Abstract

Gastric cancer mortality has declined markedly around the world. In South Australia, the reduction approximated 40% over the last 20 years. Possible reasons include: better refrigeration; reduced consumption of salted, smoked, and chemically preserved foods; increased intake of fruit and vegetables; and improved living standards and a greater use of antibiotics, which may have reduced Helicobacter pylori infection. Reductions generally have been greater for intestinal than diffuse histopathologies. Gastric cancer remains the second leading cause of cancer death worldwide, probably accounting for about 10% of newly diagnosed cancers. High rates apply to Japan, China, Central and South America, Eastern Europe, and parts of the Middle East, and low rates to North America, Australia and New Zealand, Northern Europe, and India. Rates usually are higher in lower socioeconomic groups. Five-year relative survivals of around 20% or less are frequently reported. A figure of 50% or more has been cited for Japan, where there has been radiological screening, although this exceptional figure could have been affected artificially by lead-time and related effects. Male-to-female incidence ratios generally are in the 1.5–2.5 range, with higher ratios for intestinal than diffuse cancers and higher-risk populations. In South Australia, the ratio has been 1.8 to one, although higher at 4.6 to one for cardia lesions. Recent increases in cardia cancers, especially in males in populations of European extraction, often are accompanied by increases for esophageal adenocarcinoma. It is estimated that the global burden of gastric cancer could be reduced by up to 50% by dietary changes that included an increased intake of fruit and vegetables.

Key words

Gastric cancer Incidence Mortality Survival Cardia lesions 

References

  1. 1.
    Aoki, KKurihara, MHayakawa, NSuzuki, S eds. 1992Death rates for malignant neoplasms for selected sites by sex and 5-year age group in 33 countries 1953–57 to 1983–87University of Nagoya Coop PressNagoya, JapanGoogle Scholar
  2. 2.
    Ries, LAEisner, MPKosary, CLHankey, BFMiller, BAClegg, LEdwards, BK eds. 2000SEER Cancer Statistics Review 1973–1999National Cancer InstituteBethesda, MDTable I-3Google Scholar
  3. 3.
    Coleman, MPEsteve, JDamiecki, PArslan, ARenard, H eds. 1993Trends in cancer incidence and mortality. IARC Scientific Publications No. 121International Agency for Research on CancerLyon193224Google Scholar
  4. 4.
    Kono, S 2001Supercourse. Gastric cancer epidemiologyKyushu University School of MedicineFukuokaGoogle Scholar
  5. 5.
    South Australian Cancer Registry1998Epidemiology of cancer in South Australia. Incidence, mortality and survival; 1977 to 1997. Incidence and mortality; 1997OpenbookAdelaideGoogle Scholar
  6. 6.
    South Australian Cancer Registry1999Epidemiology of cancer in South Australia. Incidence, mortality and survival; 1977 to 1998. Incidence and mortality; 1998OpenbookAdelaideGoogle Scholar
  7. 7.
    South Australian Cancer Registry2000Epidemiology of cancer in South Australia. Incidence, mortality and survival; 1977 to 1999. Incidence and mortality; 1999OpenbookAdelaideGoogle Scholar
  8. 8.
    Parkin, DMWhelan, SLFerlay, JRaymond, LYoung, J eds. 1997Cancer incidence in five continents, volume VII. IARC Scientific Publications No. 143International Agency for Research on CancerLyonGoogle Scholar
  9. 9.
    Nomura, A 1996

    Stomach cancer

    Schottenfeld, DFraumeni, JF eds. Cancer epidemiology and prevention2nd EdOxford University PressNew York70724
    Google Scholar
  10. 10.
    Tsugane, S, Akabane, M, Inami, T, Matsushima, S, Ishibashi, T, Ichinowatari, Y,  et al. 1991Urinary salt excretion and stomach cancer mortality among four Japanese populationsCancer Causes Control21658PubMedCrossRefGoogle Scholar
  11. 11.
    South Australian Cancer Registry1993Epidemiology of cancer in South Australia. Incidence, mortality and survival; 1977–1992. Incidence and mortality; 1992Lutheran Publishingp 11–22AdelaideGoogle Scholar
  12. 12.
    Murakami, R, Tsukuma, H, Ubukata, T, Nakanishi, K, Fujimoto, I, Kawashima, T,  et al. 1990Estimation of validity of mass screening program for gastric cancer in Osaka, JapanCancer65125560PubMedGoogle Scholar
  13. 13.
    Hisamuchi, S, Fukao, P, Sugawara, N, Nishikouri, M, Komatsu, S, Tsuji, I,  et al. 1991

    Evaluation of mass screening programme for stomach cancer in Japan

    Miller, ABChamberlain, JDay, NEHakama, MProrok, PC eds. Cancer screeningCambridge University PressCambridge35772
    Google Scholar
  14. 14.
    Nguyen, AM, Priest, K, McCaul, K, Roder, DM 1999South Australian Health Statistics Chartbook, 1998–99 editionDepartment of Human ServicesAdelaide634Google Scholar
  15. 15.
    Munoz, N, Matko, I 1972Histological types of gastric cancer and its relationship with intestinal metaplasiaCancer Res3999105Google Scholar
  16. 16.
    Correa, P, Chen, V 1994

    Gastric cancer

    Doll, RFraumeni, JFMuir, CS eds. Trends in cancer incidence and mortalityCold Spring Harbor Laboratory PressNew York5576
    Google Scholar
  17. 17.
    Karpeh, MS, Kelsen, DP, Tepper, JE 1993

    Cancer of the stomach

    DeVita, VTHellman, SRosenberg, SA eds. Cancer: Principles and practice of oncologyLippincott, Williams and WilkinsPhiladelphia1092122
    Google Scholar
  18. 18.
    Fuchs, CS, Mayer, RJ 1995Gastric carcinomaNew Engl J Med3333241PubMedGoogle Scholar
  19. 19.
    Terry, P, Nyren, O, Yuen, J 1998Protective effects of fruits and vegetables on stomach cancer in a cohort of Swedish twinsInt J Cancer76357PubMedCrossRefGoogle Scholar
  20. 20.
    Ekstrom, AM, Serafini, M, Nyren, O, Hansson, LE, Ye, W, Wolk, A 2000Dietary antioxidant intake and risk of cardia cancer and noncardia cancer of the intestinal types: a population-based case-control study in SwedenInt J Cancer8713340PubMedGoogle Scholar
  21. 21.
    Lauren, P 1965The two histological main types of gastric carcinoma. Diffuse and so-called intestinal-typeActa Pathol Microbiol Scand643149PubMedGoogle Scholar
  22. 22.
    Munoz, N, Asvall, J 1971Time trends of intestinal and diffuse types of gastric cancer in NorwayInt J Cancer814457PubMedGoogle Scholar
  23. 23.
    Correa, P, Sasano, N, Stemmermann, GN, Haenszel, W 1973Pathology of gastric carcinoma in Japanese populations: comparisons between Miyagi Prefecture, Japan, and HawaiiJ Natl Cancer Inst51144959PubMedGoogle Scholar
  24. 24.
    Lopez-Abente, OG, Pollan, SM, Ruiz, TM, Jimenez, M, Vazquez, F 1992La mortalidad por cancer in Espana, 1952–86Centro Nacional de EpidemiologiaMadridGoogle Scholar
  25. 25.
    Surveillance, Epidemiology, and End Results (SEER) Program Public Use Data (1973–1998), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, release April 2001, based on August 2000 submissionGoogle Scholar
  26. 26.
    Kaneko, E, Nakamura, T, Umeda, N, Fujino, M, Niwa, H 1977Outcomes of gastric carcinoma detected by gastric mass screening in JapanGut1862630PubMedGoogle Scholar
  27. 27.
    Kampschoer, GH, Fujii, A, Masuda, Y 1989Gastric cancer detected by mass survey: comparison between mass survey and outpatient detectionScand J Gastroenterol2481317PubMedGoogle Scholar
  28. 28.
    Oshima, A, Hirata, N, Ubukata, T, Umeda, K, Fujimoto, I 1986Evaluation of mass screening program for stomach cancer with a case-control study designInt J Cancer3882933PubMedGoogle Scholar
  29. 29.
    Hirayama, T, Hisamichi, S, Fujimoto, I, Oshima, A, Tominaga, S 1985

    Screening for gastric cancer

    Miller, AB eds. Screening for cancerAcademicNew York36776
    Google Scholar
  30. 30.
    Tytgat, GN, Mathus-Vliegen, EM, Offerhaus, J 1983

    Value of endoscopy in the surveillance of high-risk groups for gastrointestinal cancer

    Sherlock, PMorson, BCVeronesi, UBarbara, L eds. Precancerous lesions of the gastrointestinal tractRavenNew York30518
    Google Scholar
  31. 31.
    Ekstrom AM. Factors related to the occurrence of gastric adenocarcinoma. Doctoral thesis. Stockholm: Karolinska Institutet; 2000Google Scholar
  32. 32.
    South Australian Cancer Registry1997Epidemiology of cancer in South Australia. Incidence, mortality and survival, 1977 to 1996. Incidence and mortality, 1996OpenbookAdelaide119Google Scholar
  33. 33.
    Tajima, K, Tominaga, S 1985Dietary habits and gastrointestinal cancers: a comparative case-control study of stomach and large intestinal cancers in Nagoya, JapanJpn J Cancer Res (Gann)7670516Google Scholar
  34. 34.
    Jedrychowski, W, Wahrendorf, J, Popiela, T, Rachtan, J 1986A case-control study of dietary factors and stomach cancer risk in PolandInt J Cancer3783742PubMedGoogle Scholar
  35. 35.
    You, WC, Blot, WJ, Chang, YS, Ershow, AG, Yang, ZT, An, Q,  et al. 1988Diet and high risk of stomach cancer in Shandong, ChinaCancer Res48351823PubMedGoogle Scholar
  36. 36.
    Mirvish, SS 1983The etiology of gastric cancer. Intragastric nitrosamide formation and other theoriesJ Natl Cancer Inst7162947PubMedGoogle Scholar
  37. 37.
    Ekstrom, AM, Eriksson, M, Hansson, LE, Lindgren, A, Signorello, LB, Nyren, O,  et al. 1999Occupational exposures and risk of gastric cancer in a population-based case-control studyCancer Res5959327PubMedGoogle Scholar
  38. 38.
    Buiatti, E, Palli, D, Decarli, A, Amadori, D, Avellini, C, Bianchi, S,  et al. 1990A case-control study of gastric cancer and diet in Italy: II. Association with nutrientsInt J Cancer45869901Google Scholar
  39. 39.
    Potter, J eds. 1997Food, nutrition and the prevention of cancer: a global perspectiveAmerican Institute for Cancer Research (and World Cancer Research Fund)Washington, DC14875Google Scholar
  40. 40.
    Ohgaki, H, Hasegawa, H, Kusama, K, Morino, K, Matsukura, N, Sata, S,  et al. 1986Induction of gastric carcinomas in nonhuman primates by N-ethyl-N′-nitro-N-nitrosoguanidineJ Natl Cancer Inst7717986PubMedGoogle Scholar
  41. 41.
    Nakamura, K 1977Stomach cancer in atomic-bomb survivorsLancetII8667Google Scholar
  42. 42.
    Court Brown, WM, Doll, R 1965Mortality from cancer and other causes after radiotherapy for ankylosing spondylitisBMJ2132732Google Scholar
  43. 43.
    Fendrick, AM, Chernew, ME, Hirth, RA, Bloom, BS, Bandekar, RR, Scheiman, JM 1999Clinical and economic effects of population-based Helicobacter pylori screening to prevent gastric cancerArch Intern Med1591428PubMedCrossRefGoogle Scholar
  44. 44.
    Correa, P 1992Human gastric carcinogenesis. A multistep and multifactorial process. First American Cancer Society Award Lecture in Cancer Epidemiology and PreventionCancer Res52673540PubMedGoogle Scholar
  45. 45.
    Hansson, LE, Nyren, O, Hsing, AW, Bergstrom, R, Josefsson, S, Chow, WH 1996The risk of stomach cancer in patients with gastric or duodenal ulcer diseaseNew Engl J Med3352429PubMedCrossRefGoogle Scholar
  46. 46.
    Palli, D, Galli, M, Caporaso, NE, Cipriani, F, Decarli, A, Saieva, C,  et al. 1994Family history and risk of stomach cancer in ItalyCancer Epidemiol Biomarkers Prev3158PubMedGoogle Scholar
  47. 47.
    Tomatis, L eds. 1990Cancer: causes, occurrence and control. IARC Scientific Publications No. 100International Agency for Research on CancerLyon3301Google Scholar

Copyright information

© International and Japanese Gastric Cancer Associations 2002

Authors and Affiliations

  • David M. Roder
    • 1
  1. 1.Centre for Cancer Control ResearchThe Cancer Council South AustraliaUnleyAustralia

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