Chinese Journal of Polymer Science

, Volume 32, Issue 11, pp 1479–1488 | Cite as

Tetraphenylethene end-capped polyethylenimine fluorescent nanoparticles for cell imaging

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Abstract

Water soluble tetraphenylethene-based (TPE) aggregation-induced emission fluorescent organic nanoparticles (FONs) were facilely prepared via Schiff base condensation with polyethylenimine (PEI) and subsequent reduction. The obtained TPE-PEI FONs were characterized by a series of techniques including 1H-NMR, 13C-NMR, gel permeation chromatography, UV absorption spectra, fluorescence spectra, Fourier transform infrared spectroscopy, size distribution and zeta potential measurement, and transmission electron microscopy. Biocompatibility evaluation and cell imaging of TPE-PEI FONs were further explored. We demonstrated that such FONs showed intense fluorescence, spherical morphology and excellent biocompatibility, making them very suitable for cell imaging application.

Keywords

Aggregation-induced emission Polyethylenimine Schiff base condensation Fluorescent organic nanoparticles Cell imaging 
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Copyright information

© Chinese Chemical Society, Institute of Chemistry, Chinese Academy of Sciences and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Chemistry and the Center for Frontier Polymer ResearchTsinghua UniversityBeijingChina

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