Holmium laser technologies versus photoselective greenlight vaporization for patients with benign prostatichyperplasia: a meta-analysis

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This study aims to compare the efficacy and safety of holmium laser technologies (HoL-Ts) and photoselective greenlight vaporization (PVP) for the treatment of benign prostatic hyperplasia (BPH), and to perform a meta-analysis according to the Preferred Reporting Items of Systematic Reviews and Meta-Analyses guidelines on PubMed, EMBASE,, and the Cochrane Central Register of Controlled Trials up to August 2019. Functional outcomes, perioperative parameters, and complications were included and analyzed. Review Manager 5.3 (Cochrane Collaboration, Oxford, UK) was used to perform all analyses. A total of six articles composed of 2014 patients were included in this review. In comparison with PVP, HoL-Ts had a better performance in 1-, 3-, and 6-month Qmax (P = 0.02, but I2 = 81%), with less postvoid residual urine volume (PVR) (MD = −33.85, 95% CI −52.13 to −15.57, P = 0.0003) and less total energy used (MD = −31.66, 95% CI −58.99 to −4.33, P = 0.02). Moreover, HoL-Ts had a relatively lower risk of conversion rate (OR = 0.08, 95% CI 0.01 to 0.60, P = 0.01) associated with enough enucleation and less intraoperative bleeding. Subgroup analysis of holmium laser enucleation of prostate (HoLEP) versus PVP suggested that HoLEP presented better results in 1-, 3-, 6-month and 1-year Qmax with less PVR, less energy consumption, and lower conversion rate. Compared with PVP, HoL-Ts had higher 1-, 3-, and 6-month Qmax, less PVR, and less total energy consumption with a relatively lower risk of conversion rate. In subgroup analyses, HoLEP had shown better results in accordance with all HoL-Ts. Nevertheless, well-designed RCTs including overall functional indicators are required to confirm our findings.

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We appreciated Kai-yuen Fong for English editing. This study was funded by the National Natural Science Fund of China (grant no. 81770673) and 1.3.5. project for disciplines of excellence, West China Hospital, Sichuan University (grant no. ZY2017310).

Author information

L.P., X.Z., and D.L. contributed to the study conception and design. Material preparation, data collection, and analysis were performed by L.P., J.W., Q.H., G.C., T.L., H.S., and X.Z. The first draft of the manuscript was written by L.P. and X.Z. and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Correspondence to De-yi Luo.

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Peng, L., Zheng, X., Wu, J. et al. Holmium laser technologies versus photoselective greenlight vaporization for patients with benign prostatichyperplasia: a meta-analysis. Lasers Med Sci (2020).

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  • Laser therapy
  • Prostate
  • Holmium laser technologies
  • Greenlight photoselective vaporization
  • Prostatic hyperplasia
  • Meta-analysis