Efficacy and safety of ND:YAG 1064 nm lasers for photoepilation: a systematic review

  • Débora Aparecida Oliveira ModenaEmail author
  • Ana Carolina Godoy Miranda
  • Clovis Grecco
  • Richard Eloin Liebano
  • Raquel Cristina Tancsik Cordeiro
  • Renata Michelini Guidi
Review Article


Using light sources in phototherapy has presented promising results regarding several types of facial and body skin affections for centuries. The neodymium-doped yttrium aluminum garnet (ND:YAG) 1064 nm laser has become a standard treatment in dermatology for dermatological disturbances related to the pilous follicle and the structures surrounding it. Despite the reports of its clinical benefits, few scientific studies show its actual safety and efficacy. To substantiate the effects, benefits, and safety of applying an ND:YAG 1064 laser in the epilation process during esthetic treatment, a systematic review was carried out between October 2018 and January 2019, on studies published in the last 20 years. Randomized clinical trials in humans were considered that evaluated the efficacy, safety, and benefits of ND:YAG laser application at 1064 nm wavelengths for hair removal. A total of 198 articles were identified; 58 articles remained after their titles and abstracts were read; and 21 articles were selected after the removal of duplicates. After the integral reading, 13 of these articles were included in the systematic review (734 patients). The ND:YAG 1064 nm laser presents safety and promising, beneficial effects in epilation. However, further scientific studies with better methodologic quality are necessary to better standardize ND:YAG laser therapy and clarify its parameters for photoepilation.


ND:YAG Laser Epilation 


Author contributions

Débora A. Oliveira Modena, MSc, searched for articles in databases, analyzed articles, and wrote the manuscript.

Dr. Ana Carolina Godoy Miranda searched for articles in databases, analyzed articles, and contributed to the manuscript’s writing.

Clovis Grecco, PhD, revised and contributed to writing the manuscript.

Richard Eloin Liebano, PhD, revised and contributed to writing the manuscript.

Raquel Cristina Tancsik Cordeiro, PhD, revised and contributed to writing the manuscript.

Renata Michelini Guidi revised and contributed to writing the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The research was not submitted to an ethics committee, as it was a review study.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2020

Authors and Affiliations

  • Débora Aparecida Oliveira Modena
    • 1
    • 2
    • 3
    • 5
    Email author
  • Ana Carolina Godoy Miranda
    • 2
    • 3
    • 4
  • Clovis Grecco
    • 2
    • 3
  • Richard Eloin Liebano
    • 2
    • 5
  • Raquel Cristina Tancsik Cordeiro
    • 6
  • Renata Michelini Guidi
    • 2
    • 3
    • 7
  1. 1.Department of Surgery, Medical Sciences InstituteUniversity of Campinas (Unicamp)CampinasBrazil
  2. 2.Department of ResearchDevelopment and Innovation of Ibramed, Study Group in Applied Technologies for HealthAmparoBrazil
  3. 3.Center for Advanced Studies Ibramed (CEFAI)AmparoBrazil
  4. 4.Department of Tocogynecology, Medical Sciences InstituteUniversity of Campinas (Unicamp)CampinasBrazil
  5. 5.Department of PhysiotherapyFederal University of São Carlos (UFSCar)São CarlosBrazil
  6. 6.Coordinator of the Specialized Ambulatory of CosmiatryUniversity of Campinas (Unicamp)CampinasBrazil
  7. 7.Department of Biomedical Engineering, Electrical and Computing Engineering InstituteUniversity of Campinas (Unicamp)CampinasBrazil

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