High-power therapeutic ultrasound for treatment of abdominal localized adiposity—double-blind randomized clinical trial
This study aimed to evaluate the effects of high-power therapeutic ultrasound in the treatment of abdominal localized adiposity in an isolated manner, with the use of neutral gel comparing ultrasonic application with 5% lipolytic active caffeine gel (phonophoresis). A total of 90 healthy women aged between 18 and 40 years were randomized and divided into two groups. The volunteers underwent anamnesis evaluation, perimetry, bioimpedance, ultrasound examination, and blood tests (complete lipidogram, creatinine, and vitamin D) before and after the end of the 10-session ultrasound protocol (3 MHz, 2 W/cm2, and 30w). Comparisons between groups and pre-post evaluation were performed by a two-way repeated-measures analysis of variance. Values of p < 0.05 indicated statistical significance. The results demonstrated a significant reduction in both groups, for the perimetry (p < 0.001) and measurements of adipose tissue thickness (p < 0.001). The examinations exhibited a significant alteration only of the complete lipidogram, but without significance (p > 0.05). When comparing the groups, no statistically significant difference was identified in any of the analyzed parameters. The high-power ultrasonic therapy is efficient in reducing localized adiposity, regardless of whether it is applied with neutral gel or 5% caffeine gel.
KeywordsTherapeutic ultrasound Phonophoresis High-power Localized adiposity Lipocavitation
Financial support was received from the Brazilian Coordination for the Improvement of Higher Education Personnel (CAPES), the National Council for Scientific and Technological Development (CNPq, No. 306508/2015-0), the Brazilian Study and Project Funding Agency (FINEP, No. 2613/2009), the Araucária Foundation (No. 05/2011-10404), and the Brazilian Ministry of Health (No. 2210/2008).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This study was approved by the Research Ethics Committee (CEP) of the Federal University of Technology—Paraná (UTFPR) via Plataforma Brasil, Protocol No. 1956753 of March 9, 2017, in accordance with resolution 466/2012 of the National Health Council.
Informed consent was obtained from all individual participants included in the study.
- 2.Lima WA, Glaner MF (2006) Main factors of risk related to the cardiovascular diseases. Rev Bras Cineantropom Desenvolvimento Humano 8:96–104Google Scholar
- 4.Borges F (2010) Modalidades terapêuticas nas disfunções estéticas, 2nd edn. Editora Phorte, São PauloGoogle Scholar
- 5.Niwa A, Shono M, Mônaco P, Prado G, Osário N (2010) Experience in the use of focused ultrasound in the treatment of localized fat. Surg Cosmet Dermatol 2:323–325Google Scholar
- 9.Sant'ana EMC (2010) Fundamentação teórica para terapia combinada heccus® - ultrassom e corrente aussie no tratamento da lipodistrofia ginóide e da gordura localizada. Rev Bras de Ciência & Estética 1Google Scholar
- 11.Mendonça AG, Rodrigues RD, Corradi DP, Cruz LB, Meyer PF, Antunes MJ et al (2008) Protocolo de avaliação fisioterapêutica em adiposidade localizada. Fisioterapia Brasil 2008:26–31Google Scholar
- 12.Hoogland R (1986) Ultrasound therapy. Holanda-delf, Enrof NomiusGoogle Scholar
- 13.Brunner E, Dumhof S, Langer F, Brunner E (2002) Nonparametric analysis of longitudinal data in factorial experiments, 1st edn. Wiley, New YorkGoogle Scholar
- 14.Savoia A, Forenza AM, Vannini F, Alberto F, Marino MPD, Baldi A (2010) Noninvasive body contouring by low frequency ultrasound: a clinical study. Open Recons Cosmet Surg 3:11–16Google Scholar
- 15.Meyer PF, Carvalho MGF, Andrade LL, Souza RN, Delgado AM et al (2012) Ultra-cavitation effect in adipose tissue of rabbits. Fisioterapia Brasil 13:106–111Google Scholar
- 17.Polacow ML, Pires de Campos MS, Leonardi GR, Ribeiro MC, Montebello MI (2004) Effect of ultrasound on cutaneous permeation of tiratricol: histological analysis. Braz J Phys Ther 8:53–60Google Scholar
- 18.Guirro ECO, Guirro RRJ (2002) Fisioterapia dermato-funcional: fundamentos - recursos - patologias, 3a edn. Ed Manole, São PauloGoogle Scholar