Lasers in Medical Science

, Volume 35, Issue 2, pp 373–378 | Cite as

Comparison of efficacy and safety of a novel 755-nm diode laser with conventional 755-nm alexandrite laser in reduction of axillary hairs

  • Azin Ayatollahi
  • Aniseh Samadi
  • Ali Rajabi-Estarabadi
  • Somayeh Yadangi
  • Keyvan Nouri
  • Alireza FiroozEmail author
Original Article


The aim of this study was to compare the efficacy and safety of a novel diode system emitting 755 nm wavelength with conventional 755 nm alexandrite laser in skin types III and IV. It was a randomized, right-left comparison, assessor-blind, clinical study. Sixteen female volunteers age 29.52 ± 9.52 were randomly assigned to receive six treatment sessions using 755 nm diode laser on one axilla and 755 nm alexandrite on the opposite axilla. Efficacy was assessed by counting of hairs per square centimeter, 6 months after the last treatment. Treatment outcome was also evaluated by blind reviewing of before and after pictures, using Physician Global Assessment scale (GAS). Subject satisfaction was assessed using visual analogue scale (VAS), pain level and adverse effects were recorded. Skin biophysical parameters (transepidermal water loss, skin sebum, and erythema index) were also measured. Significant reduction in hair count was observed, 6 months after the last treatment session, for both devices (− 33% for 755 nm diode and − 35% for 755 nm alexandrite; p value = 0.85). The mean GAS score was 2.66 for alexandrite treated side vs. 2.00 for diode treated side (p value = 0.036). No severe adverse events were reported. The subject satisfaction score was significantly higher after treatment with alexandrite laser. No significant changes were detected in none of skin biophysical parameters. 755 nm diode laser is suitable for hair removal procedures and it is as effective and safe as the 755 nm alexandrite laser in skin types III–IV.


755 nm Diode laser Alexandrite laser Hair removal 


Funding information

This study was supported by research grant number 943717 from National Institute for Medical Research Development (NIMAD), Ministry of Health, Iran.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2019

Authors and Affiliations

  • Azin Ayatollahi
    • 1
  • Aniseh Samadi
    • 1
  • Ali Rajabi-Estarabadi
    • 2
  • Somayeh Yadangi
    • 1
  • Keyvan Nouri
    • 2
  • Alireza Firooz
    • 1
    Email author
  1. 1.Center for Research & Training in Skin Diseases and LeprosyTehran University of Medical SciencesTehranIran
  2. 2.Dermatology and Cutaneous SurgeryUniversity of Miami School of MedicineMiamiUSA

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