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Acute low-level laser therapy effects on peripheral muscle strength and resistance in patients with fibromyalgia

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  1. 1.

    Bachasson D, Guinot M, Wuyam B, Favre-Juvin A, Millet GY, Levy P, Verges S (2013) Neuromuscular fatigue and exercise capacity in fibromyalgia syndrome. Arthritis Care Res 65(3):432–440. https://doi.org/10.1002/acr.21845

  2. 2.

    Carbonell-Baeza A, Aparicio VA, Sjostrom M, Ruiz JR, Delgado-Fernandez M (2011) Pain and functional capacity in female fibromyalgia patients. Pain Med 12(11):1667–1675. https://doi.org/10.1111/j.1526-4637.2011.01239.x

  3. 3.

    Henriksen M, Lund H, Christensen R, Jespersen A, Dreyer L, Bennett RM, Danneskiold-Samsoe B, Bliddal H (2009) Relationships between the fibromyalgia impact questionnaire, tender point count, and muscle strength in female patients with fibromyalgia: a cohort study. Arthritis Rheum 61(6):732–739. https://doi.org/10.1002/art.24512

  4. 4.

    Maquet D, Croisier JL, Renard C, Crielaard JM (2002) Muscle performance in patients with fibromyalgia. Joint Bone Spine 69(3):293–299

  5. 5.

    Panton LB, Kingsley JD, Toole T, Cress ME, Abboud G, Sirithienthad P, Mathis R, McMillan V (2006) A comparison of physical functional performance and strength in women with fibromyalgia, age- and weight-matched controls, and older women who are healthy. Phys Ther 86(11):1479–1488. https://doi.org/10.2522/ptj.20050320

  6. 6.

    Bengtsson A (2002) The muscle in fibromyalgia. Rheumatology (Oxford) 41(7):721–724

  7. 7.

    Lindman R, Hagberg M, Bengtsson A, Henriksson KG, Thornell LE (1995) Capillary structure and mitochondrial volume density in the trapezius muscle of chronic trapezius myalgia, fibromyalgia and healthy subjects. J Musculoskeletal Pain 3(3):5–22. https://doi.org/10.1300/J094v03n03_02

  8. 8.

    Hakkinen A, Hakkinen K, Hannonen P, Alen M (2001) Strength training induced adaptations in neuromuscular function of premenopausal women with fibromyalgia: comparison with healthy women. Ann Rheum Dis 60(1):21–26

  9. 9.

    da Silva MM, Albertini R, Leal-Junior EC, de Tarso Camillo de Carvalho P, Silva JA Jr, Bussadori SK, de Oliveira LV, Casarin CA, Andrade EL, Bocalini DS, Serra AJ (2015) Effects of exercise training and photobiomodulation therapy (EXTRAPHOTO) on pain in women with fibromyalgia and temporomandibular disorder: study protocol for a randomized controlled trial. Trials 16:252. https://doi.org/10.1186/s13063-015-0765-3

  10. 10.

    de Carvalho Pde T, Leal-Junior EC, Alves AC, Rambo CS, Sampaio LM, Oliveira CS, Albertini R, de Oliveira LV (2012) Effect of low-level laser therapy on pain, quality of life and sleep in patients with fibromyalgia: study protocol for a double-blinded randomized controlled trial. Trials 13:221. https://doi.org/10.1186/1745-6215-13-221

  11. 11.

    Kingsley JD, Demchak T, Mathis R (2014) Low-level laser therapy as a treatment for chronic pain. Front Physiol 5:306. https://doi.org/10.3389/fphys.2014.00306

  12. 12.

    Gur A, Karakoc M, Nas K, Cevik R, Sarac J, Demir E (2002) Efficacy of low power laser therapy in fibromyalgia: a single-blind, placebo-controlled trial. Lasers Med Sci 17(1):57–61. https://doi.org/10.1007/s101030200010

  13. 13.

    Vayvay ES, Tok D, Turgut E, Tunay VB (2016) The effect of laser and taping on pain, functional status and quality of life in patients with fibromyalgia syndrome: a placebo- randomized controlled clinical trial. J Back Musculoskelet Rehabil 29(1):77–83. https://doi.org/10.3233/BMR-150600

  14. 14.

    Staud R, Nagel S, Robinson ME, Price DD (2009) Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled study. Pain 145(1–2):96–104. https://doi.org/10.1016/j.pain.2009.05.020

  15. 15.

    Yokoyama T, Lisi TL, Moore SA, Sluka KA (2007) Muscle fatigue increases the probability of developing hyperalgesia in mice. J Pain 8(9):692–699. https://doi.org/10.1016/j.jpain.2007.05.008

  16. 16.

    de Freitas LF, Hamblin MR (2016) Proposed mechanisms of photobiomodulation or low-level light therapy. IEEE J Sel Top Quantum Electron 22(3):7000417. https://doi.org/10.1109/JSTQE.2016.2561201

  17. 17.

    Wang X, Tian F, Soni SS, Gonzalez-Lima F, Liu H (2016) Interplay between up-regulation of cytochrome-c-oxidase and hemoglobin oxygenation induced by near-infrared laser. Sci Rep 6:30540. https://doi.org/10.1038/srep30540

  18. 18.

    Marques AP, Santos AMB, Assumpção A, Matsutani LA, Lage LV, Pereira CAB (2006) Validation of the Brazilian version of the Fibromyalgia Impact Questionnaire (FIQ). Rev Bras Reumatol 46(1):24–31

  19. 19.

    Ruaro JA, Frez AR, Ruaro MB, Nicolau RA (2014) Low-level laser therapy to treat fibromyalgia. Lasers Med Sci 29(6):1815–1819. https://doi.org/10.1007/s10103-014-1566-8

  20. 20.

    Hooten WM, Smith JM, Eldrige JS, Olsen DA, Mauck WD, Moeschler SM (2014) Pain severity is associated with muscle strength and peak oxygen uptake in adults with fibromyalgia. J Pain Res 7:237–242. https://doi.org/10.2147/JPR.S61312

  21. 21.

    Casale R, Atzeni F, Sarzi-Puttini P (2012) Neurophysiological background for physical therapies in fibromyalgia. Reumatismo 64(4):238–249. https://doi.org/10.4081/reumatismo.2012.238

  22. 22.

    Leal Junior EC, Lopes-Martins RA, Frigo L, De Marchi T, Rossi RP, de Godoi V, Tomazoni SS, Silva DP, Basso M, Filho PL, de Valls Corsetti F, Iversen VV, Bjordal JM (2010) Effects of low-level laser therapy (LLLT) in the development of exercise-induced skeletal muscle fatigue and changes in biochemical markers related to postexercise recovery. J Orthop Sports Phys Ther 40(8):524–532. https://doi.org/10.2519/jospt.2010.3294

  23. 23.

    Germano Maciel D, Trajano da Silva M, Rodrigues JA, Viana Neto JB, de Franca IM, Melo ABM, Barros da Silva TYP, de Brito Vieira WH (2018) Low-level laser therapy combined to functional exercise on treatment of fibromyalgia: a double-blind randomized clinical trial. Lasers Med Sci 33(9):1949–1959. https://doi.org/10.1007/s10103-018-2561-2

  24. 24.

    da Silva MM, Albertini R, de Tarso Camillo de Carvalho P, Leal-Junior ECP, Bussadori SK, Vieira SS, Bocalini DS, de Oliveira LVF, Grandinetti V, Silva JA Jr, Serra AJ (2018) Randomized, blinded, controlled trial on effectiveness of photobiomodulation therapy and exercise training in the fibromyalgia treatment. Lasers Med Sci 33(2):343–351. https://doi.org/10.1007/s10103-017-2388-2

  25. 25.

    Ash C, Dubec M, Donne K, Bashford T (2017) Effect of wavelength and beam width on penetration in light-tissue interaction using computational methods. Lasers Med Sci 32(8):1909–1918. https://doi.org/10.1007/s10103-017-2317-4

  26. 26.

    Cardoso FS, Curtolo M, Natour J, Lombardi Júnior I (2011) Assessment of quality of life, muscle strength and functional capacity in women with fi bromyalgia. Rev Bras Reumatol 51(4):338–350

  27. 27.

    Wang X, Reddy DD, Nalawade SS, Pal S, Gonzalez-Lima F, Liu H (2018) Impact of heat on metabolic and hemodynamic changes in transcranial infrared laser stimulation measured by broadband near-infrared spectroscopy. Neurophotonics 5(1):011004. https://doi.org/10.1117/1.NPh.5.1.011004

  28. 28.

    Dos Reis FA, da Silva BA, Laraia EM, de Melo RM, Silva PH, Leal-Junior EC, de Carvalho Pde T (2014) Effects of pre- or post-exercise low-level laser therapy (830 nm) on skeletal muscle fatigue and biochemical markers of recovery in humans: double-blind placebo-controlled trial. Photomed Laser Surg 32(2):106–112. https://doi.org/10.1089/pho.2013.3617

  29. 29.

    Felismino AS, Costa EC, Aoki MS, Ferraresi C, de Araujo Moura Lemos TM, de Brito Vieira WH (2014) Effect of low-level laser therapy (808 nm) on markers of muscle damage: a randomized double-blind placebo-controlled trial. Lasers Med Sci 29(3):933–938. https://doi.org/10.1007/s10103-013-1430-2

  30. 30.

    Vanin AA, Miranda EF, Machado CS, de Paiva PR, Albuquerque-Pontes GM, Casalechi HL, de Tarso Camillo de Carvalho P, Leal-Junior EC (2016) What is the best moment to apply phototherapy when associated to a strength training program? A randomized, double-blinded, placebo-controlled trial: phototherapy in association to strength training. Lasers Med Sci 31(8):1555–1564. https://doi.org/10.1007/s10103-016-2015-7

  31. 31.

    Cassano P, Tran AP, Katnani H, Bleier BS, Hamblin MR, Yuan Y, Fang Q (2019) Selective photobiomodulation for emotion regulation: model-based dosimetry study. Neurophotonics 6(1):015004. https://doi.org/10.1117/1.NPh.6.1.015004

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This study was funded by CNPQ and the University of Fortaleza (grant number 2511).

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Correspondence to Mayron F. Oliveira.

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This study was approved by the Institutional Ethics Committee (number 2,257,424).

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The authors declare that they have no conflict of interest.

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dos Santos, R.C., Souza Guedes, K.W.H.S., de Sousa Pinto, J.M. et al. Acute low-level laser therapy effects on peripheral muscle strength and resistance in patients with fibromyalgia. Lasers Med Sci 35, 505–510 (2020). https://doi.org/10.1007/s10103-019-02816-2

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