Combination laser therapy as a non-surgical method for treating congenital melanocytic nevi from cosmetically sensitive locations on the body

  • Emi FunayamaEmail author
  • Yuhei Yamamoto
  • Akihiko Oyama
  • Naoki Murao
  • Toshihiko Hayashi
  • Taku Maeda
  • Hiroshi Furukawa
  • Masayuki Osawa
Brief Report


Where possible, the treatment of choice for medium-sized congenital melanocytic nevi (CMNs) is full-thickness surgical excision. However, for CMNs located on anatomical landmarks (e.g., nipple/areola, eyebrow, auricle, lip, eyelid, and nose), excision can yield esthetically and functionally undesirable results. Thus, treatment of medium-sized CMNs can be challenging. Treatment options for CMNs have been reviewed extensively, and the evolution of laser technology has made lasers a viable treatment option. We previously reported the efficacy of a pulsed dye laser (PDL), which was originally used for vascular malformations, in combination with a Q-switched ruby laser (QsRL) in reducing the number of nevus cells in giant CMNs [1]. PDLs are also highly absorbed by melanin, and the pulse duration is much longer than that of Q-switched pigment-specific lasers. PDLs may have strong photothermolytic effects on surrounding nevus cells not containing melanin. These features...


Compliance with ethical standards

Informed consent was obtained from all patients. This study was approved by the institutional review board of the Hokkaido University Hospital.

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10103_2019_2753_MOESM1_ESM.pdf (58 kb)
ESM 1 (PDF 58 kb)


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2019

Authors and Affiliations

  • Emi Funayama
    • 1
    Email author
  • Yuhei Yamamoto
    • 1
  • Akihiko Oyama
    • 2
  • Naoki Murao
    • 1
  • Toshihiko Hayashi
    • 1
  • Taku Maeda
    • 1
  • Hiroshi Furukawa
    • 3
  • Masayuki Osawa
    • 1
  1. 1.Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporoJapan
  2. 2.Department of Plastic and Reconstructive SurgeryFukushima Medical UniversityFukushimaJapan
  3. 3.Department of Plastic and Reconstructive SurgeryAichi Medical UniversityNagakuteJapan

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