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Efficacy assessment of UVA1 and narrowband UVB for treatment of scalp psoriasis

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Abstract

To compare the efficacy and safety of UVA1 and narrowband UVB (NB-UVB) therapy in the treatment of scalp psoriasis. Patients with scalp psoriasis were randomly assigned to either UVA1 or NB-UVB therapy. Both treatments were performed three times weekly for 6 weeks. Clinical efficacy was evaluated by using Psoriasis Scalp Severity Index (PSSI), and patient-reported quality of life (QoL) was assessed by Dermatology Life Quality Index (DLQI). Totally 68 patients completed the study. Both UVA1 and NB-UVB phototherapy achieved a statistically significant reduction of PSSI and DLQI scores at the end of the treatment period. Compared with the NB-UVB group, the significantly greater improvements occurred in UVA1 treatment group at week 3, although differences declined thereafter through week 10. Both UVA1 and NB-UVB therapy were well-tolerated in this study, and the occurrence of adverse events (AEs) was uncommon. Both UVA1 and NB-UVB phototherapy could offer relief of scalp symptoms in patients with scalp involvement. Furthermore, UVA1 treatment could improve the clinical manifestations and QoL more quickly than NB-UVB therapy.

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Funding

This study is supported by the Shanghai Municipal Commission of Health and Family Planning Foundation (Grant No: 201740245).

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Authors and Affiliations

  1. Department of Dermatology, Shanghai Skin Disease Hospital, Shanghai, China

    Jing Zhou, Xuemei Yi, Ying Li & Yangfeng Ding

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  1. Jing Zhou
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  2. Xuemei Yi
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  3. Ying Li
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  4. Yangfeng Ding
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Correspondence to Yangfeng Ding.

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Zhou, J., Yi, X., Li, Y. et al. Efficacy assessment of UVA1 and narrowband UVB for treatment of scalp psoriasis. Lasers Med Sci 33, 1979–1982 (2018). https://doi.org/10.1007/s10103-018-2564-z

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  • DOI: https://doi.org/10.1007/s10103-018-2564-z

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