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Evaluation of the therapeutic effect of micro-plasma radio frequency on hypertrophic scars in rabbit ears

  • Wen Zhang
  • Xingjian Cheng
  • Huizheng Li
  • Mo Cao
Original Article
  • 27 Downloads

Abstract

To evaluate the therapeutic effect of micro-plasma radio frequency on hypertrophic scars in rabbit ears to provide an experimental basis and theoretical foundation for the treatment of hypertrophic scars. Hypertrophic scars were established on the ventral surface of the ears of six New Zealand white rabbits. Left and right ears were randomly divided into two groups: experimental group treated with micro-plasma radio frequency and control group with no treatment. H&E staining and CD34 labeling of microvessels were performed to analyze ear specimens, and immunohistochemical staining was conducted to detect IL-8 and MCP-1 in the scars. Compared with the control group, scar tissue in the experimental group was improved by color and texture. H&E-stained collagen fiber bundles were more organized after treatment as assessed by optical microscopy. The number of microvessels in the experimental group was decreased compared with that in the control group. Microvascular density was significantly reduced in the experimental group compared with the control group (27.16 ± 5.64 and 48.75 ± 8.25 mm2, respectively; P < 0.01). The mean optical densities of IL-8 and MCP-1 were significantly reduced in the experimental group compared with the control group (IL-8 0.016 ± 0.011 and 0.078 ± 0.023, respectively; MCP-1 0.018 ± 0.016 and 0.054 ± 0.038, respectively; both P < 0.01). The micro-plasma radio-frequency technique has a therapeutic effect on hypertrophic scars in rabbit ears.

Keywords

Micro-plasma radio-frequency technique Hypertrophic scar Microvascular IL-8 MCP-1 

Notes

Compliance with ethical standards

Conflict of interest statement

The authors declare that they have no conflict of interest.

Ethical approval

The present study was approved by our institutional review board.

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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  • Wen Zhang
    • 1
  • Xingjian Cheng
    • 1
  • Huizheng Li
    • 1
  • Mo Cao
    • 1
  1. 1.Department of Plastic Surgerythe Third Hospital of Hebei Medical UniversityShijiazhuangPeople’s Republic of China

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