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The effects of exercise training associated with low-level laser therapy on biomarkers of adipose tissue transdifferentiation in obese women

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Abstract

Investigations suggest the benefits of low-level laser therapy (LLLT) to improve noninvasive body contouring treatments, inflammation, insulin resistance and to reduce body fat. However, the mechanism for such potential effects in association with exercise training (ET) and possible implications in browning adiposity processes remains unclear. Forty-nine obese women were involved, aged between 20 and 40 years with a body mass index (BMI) of 30–40 kg/m2. The volunteers were divided into Phototherapy (808 nm) and SHAM groups. Interventions consisted of exercise training and phototherapy applications post exercise for 4 months, with three sessions/week. Body composition, lipid profile, insulin resistance, atrial natriuretic peptide (ANP), WNT5 signaling, interleukin-6 (IL-6), and fibroblast growth factor-21 (FGF-21) were measured. Improvements in body mass, BMI, body fat mass, lean mass, visceral fat, waist circumference, insulin, HOMA-IR, total cholesterol, LDL-cholesterol, triglycerides, and ANP in both groups were demonstrated. Only the Phototherapy group showed a reduction in interleukin-6 and an increase in WNT5 signaling. In addition, it was possible to observe a higher magnitude change for the fat mass, insulin, HOMA-IR, and FGF-21 variables in the Phototherapy group. In the present investigation, it was demonstrated that exercise training associated with LLLT promotes an improvement in body composition and inflammatory processes as previously demonstrated. The Phototherapy group especially presented positive modifications of WNT5 signaling, FGF-21, and ANP, possible biomarkers associated with browning adiposity processes. This suggests that this kind of intervention promotes results applicable in clinical practice to control obesity and related comorbidities.

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Acknowledgements

We would like to thank the patients that participated of the study.

Funding

We thank the financial support for all research agencies Support Foundation of São Paulo Research—FAPESP (2013/041364; 2013/19046-0; 2013/08522-6; 2015/14309-9) and National Council for Scientific and Technological Development—CNPq (573587/2008-6; 300654/2013-8; 150177/2014-3) and Coordination of Higher Education Personnel Training—CAPES.

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Authors and Affiliations

  1. Department of Physiotherapy, Therapeutic Resources Laboratory, Universidade Federal de São Carlos (UFSCar), Rodovia Washington Luis, Km 235, São Carlos, São Paulo, 13565-905, Brazil

    Raquel Munhoz da Silveira Campos & Nivaldo Antonio Parizotto

  2. Post Graduated Program of Nutrition Paulista Medicine School, Universidade Federal de São Paulo (UNIFESP), Rua Marselhesa, 650–Vila Clementino, São Paulo, SP, 04020-050, Brazil

    Ana Raimunda Dâmaso, Ana Claudia Pelissari Kravchychyn & Lila Missae Oyama

  3. São Camilo University Center, São Paulo, Brazil

    Deborah Cristina Landi Masquio

  4. Electrical Engineering Department, Engineering School of São Carlos, Universidade de São Paulo (USP), Av. Trabalhador Sãocarlense 400, São Carlos, SP, 13566-590, Brazil

    Fernanda Oliveira Duarte

  5. São Carlos Institute of Physics, Universidade de São Paulo (USP), PO Box 369, São Carlos, SP, 13560-970, Brazil

    Marcela Sene-Fiorese, Antonio Eduardo Aquino Jr & Vanderlei Salvador Bagnato

  6. Centro de Traumato-Ortopedia do Esporte (CETE), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil

    Filippo Aragão Savioli & Liliane Isabel Guimarães

  7. Laboratório Interdisciplinar em Fisiologia e Exercício (LAIFE), São Paulo, Brazil

    Pamela Cristina Lopes Quintiliano

  8. Weight Science, São Paulo, SP, Brazil

    Lian Tock

  9. Department of Physiology Paulista Medicine School, Universidade Federal de São Paulo, São Paulo, SP, Brazil

    Lila Missae Oyama & Valter Tadeu Boldarine

  10. Post Graduated Program of Biotechnology, Universidade Federal de São Carlos (UFSCar), São Carlos, SP, 13565-905, Brazil

    Vanderlei Salvador Bagnato & Nivaldo Antonio Parizotto

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  1. Raquel Munhoz da Silveira Campos
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Correspondence to Raquel Munhoz da Silveira Campos, Ana Raimunda Dâmaso or Nivaldo Antonio Parizotto.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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da Silveira Campos, R.M., Dâmaso, A.R., Masquio, D.C.L. et al. The effects of exercise training associated with low-level laser therapy on biomarkers of adipose tissue transdifferentiation in obese women. Lasers Med Sci 33, 1245–1254 (2018). https://doi.org/10.1007/s10103-018-2465-1

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