Advertisement

Clinical efficacy of laser combined with menstrual regulation in the treatment of female melasma: a retrospective study

  • Yu Jin
  • Wenbo Jiang
  • Yonghui Yao
  • Huang HuangEmail author
  • Jinlong HuangEmail author
Original Article
  • 31 Downloads

Abstract

The aim of this study was to evaluate the clinical efficacy of using a Medlite C6 Q-switch Nd:YAG laser combined with menstrual regulation–based traditional Chinese medicine (TCM) in the treatment of female melasma. Forty cases of female patients with melasma, who were treated between December 2013 and December 2015 at the Jiangsu Provincial Hospital of Traditional Chinese Medicine, were reviewed retrospectively. Twenty patients received Q-switch Nd:YAG 1064 nm laser treatments combined with menstrual regulation treatments (experimental group), and 20 patients were treated only with the laser (control group). All treatments lasted for 6 months. The patients’ faces were photographed before, immediately, and 6 months after treatment. The therapeutic efficacy was assessed by the reduction in the Melasma Area and Severity Index (MASI) score and the total skin damage score, and this was then compared between the two groups. Immediately and 6 months after the treatment, both the MASI and total skin damage scores in the experimental group were significantly lower compared to those in the control group (P < 0.001). The experimental group had significantly higher basic recovery and effectiveness rates than the control group (P = 0.020 and P = 0.008, respectively) and had a significantly lower invalidity rate (P < 0.001). Results from Medlite C6 Q-switch Nd:YAG laser treatment combined with menstrual regulation are superior than those obtained using only a laser for the treatment of female melasma.

Keywords

Female Melasma Menstrual regulation Laser Efficacy 

Notes

Compliance with ethical standards

Ethics approval

This study was approved by the Ethics Committee of the Jiangsu Provincial Hospital of Traditional Chinese Medicine. All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all the participants included in the study.

Competing interests

The authors declare that they have no conflict of interest.

References

  1. 1.
    Choi JW (2010) Low-dose 1064-nm Q-switched Nd:YAG laser for the treatment of melasma. J Dermatolog Treat 21(4):224–228CrossRefGoogle Scholar
  2. 2.
    Zhou X, Gold MH, Lu Z, Li Y (2011) Efficacy and safety of Q-switched 1,064-nm neodymium-doped yttrium aluminum garnet laser treatment of melasma. Dermatol Surg 37(7):962–970CrossRefGoogle Scholar
  3. 3.
    Wattanakrai P, Mornchan RS (2010) Low-fluence Q-switched neodymium-doped yttrium aluminum garnet (1,064 nm) laser for the treatment of facial melasma in Asians. Dermatol Surg 36(1):76–87CrossRefGoogle Scholar
  4. 4.
    Kar HK, Gupta L, Chauhan A (2012) A comparative study on efficacy of high and low fluence Q-switched Nd:YAG laser and glycolic acid peel in melasma. Indian J Dermatol Venereol Leprol 78(2):165CrossRefGoogle Scholar
  5. 5.
    Vachiramon V, Sirithanabadeekul P, Sahawatwong S (2015) Low-fluence Q-switched Nd: YAG 1064-nm laser and intense pulsed light for the treatment of melasma. J Eur Acad Dermatol Venereol 29(7):1339–1346CrossRefGoogle Scholar
  6. 6.
    Hofbauer Parra CA, Careta MF, Valente NY, de Sanches Osorio NE, Torezan LA (2016) Clinical and histopathologic assessment of facial melasma after low-fluence Q-switched neodymium-doped yttrium aluminium garnet laser. Dermatol Surg 42(4):507–512.  https://doi.org/10.1097/dss.0000000000000653 CrossRefGoogle Scholar
  7. 7.
    Gokalp H, Akkaya AD, Oram Y (2016) Long-term results in low-fluence 1064-nm Q-switched Nd:YAG laser for melasma: is it effective? J Cosmet Dermatol 15(4):420–426.  https://doi.org/10.1111/jocd.12253 CrossRefGoogle Scholar
  8. 8.
    Nouri K, Bowes L, Chartier T, Romagosa R, Spencer J (1999) Combination treatment of melasma with pulsed CO2 laser followed by Q-switched alexandrite laser: a pilot study. Dermatol Surg 25(6):494–497CrossRefGoogle Scholar
  9. 9.
    Angsuwarangsee S, Polnikorn N (2003) Combined ultrapulse CO2 laser and Q-switched alexandrite laser compared with Q-switched alexandrite laser alone for refractory melasma: split-face design. Dermatol Surg 29(1):59–64Google Scholar
  10. 10.
    Kauvar AN (2012) Successful treatment of melasma using a combination of microdermabrasion and Q-switched Nd:YAG lasers. Lasers Surg Med 44(2):117–124.  https://doi.org/10.1002/lsm.21156 CrossRefGoogle Scholar
  11. 11.
    Bansal C, Naik H, Kar HK, Chauhan A (2012) A comparison of low-fluence 1064-nm Q-switched Nd:YAG laser with topical 20% azelaic acid cream and their combination in melasma in Indian patients. J Cutan Aesthet Surg 5(4):266–272.  https://doi.org/10.4103/0974-2077.104915 CrossRefGoogle Scholar
  12. 12.
    Shin JU, Park J, Oh SH, Lee JH (2013) Oral tranexamic acid enhances the efficacy of low-fluence 1064-nm quality-switched neodymium-doped yttrium aluminum garnet laser treatment for melasma in Koreans: a randomized, prospective trial. Dermatol Surg 39(3 Pt 1):435–442.  https://doi.org/10.1111/dsu.12060 CrossRefGoogle Scholar
  13. 13.
    Wu YH, Li QL, Yang XW (2009) Effects of Chinese herbal medicine combined with He-Ne laser on lipoperoxide and superoxide dismutase in chloasma patients. J Tradit Chin Med 29(3):163–166CrossRefGoogle Scholar
  14. 14.
    Yan-hua C, Fang L, Shi N (2011) Clinical effects of shen-nourishing and menstruation-regulating method combined with triptorelin acetate injection on patient with luteinized unruptured follicle syndrome. Zhongguo Zhong Xi Yi Jie He Za Zhi 31(12):1604–1606Google Scholar
  15. 15.
    Huang XT, Liang SR, Wang L (2014) Treatment of declining in ovarian reserve by shen-reinforcing and menstrual cycle-regulating therapy combined with western medicine: a clinical observation. Zhongguo Zhong Xi Yi Jie He Za Zhi 34(6):688–690Google Scholar
  16. 16.
    Group of pigmentary diseases of the professional board of dermatology and venereology of China association of integrated Chinese and western medicine (2004) Clinical diagnostic and therapeutic evaluation criteria of melasma (2013 revision). Chin J Dermatovenereol Integr Tradit West Med 3(1):66Google Scholar
  17. 17.
    Kimbrough-Green CK, Griffiths CE, Finkel LJ, Hamilton TA, Bulengo-Ransby SM, Ellis CN, Voorhees JJ (1994) Topical retinoic acid (tretinoin) for melasma in black patients. A vehicle-controlled clinical trial. Arch Dermatol 130(6):727–733CrossRefGoogle Scholar
  18. 18.
    Zhen Y (2008) Treatment for melasma using modified Danzhi Xiaoyao powder: a case series of 30 patients. Hebei J Tradit Chin Med 9(30):975Google Scholar
  19. 19.
    Fan H (2008) Application of syndrome differentiation of traditional Chinese medicine in the treatment of melasma: a case series of 72 patients. Chin J Dermatovenereol Integr Tradit West Med 2(7):112Google Scholar
  20. 20.
    Liu C, Zhang C (2010) Treatment of Shenlinbaizhu powder and Xuefu-Zhuyu oral liquid for melasma of spleen deficiency and dampness and blood stasis type: a case series of 60 patients. Yunnan J Tradit Chin Med Mater Med 2(31):38–39Google Scholar
  21. 21.
    Snell RS, Bischitz PG (1960) The effect of large doses of estrogen and estrogen and progesterone on melanin pigmentation. J Invest Dermatol 35:73–82CrossRefGoogle Scholar
  22. 22.
    Ranson M, Posen S, Mason RS (1988) Human melanocytes as a target tissue for hormones: in vitro studies with 1 alpha-25, dihydroxyvitamin D3, alpha-melanocyte stimulating hormone, and beta-estradiol. J Invest Dermatol 91(6):593–598CrossRefGoogle Scholar
  23. 23.
    Suh KS, Sung JY, Roh HJ, Jeon YS, Kim YC, Kim ST (2011) Efficacy of the 1064-nm Q-switched Nd:YAG laser in melasma. J Dermatol Treat 22(4):233–238.  https://doi.org/10.3109/09546631003686051 CrossRefGoogle Scholar
  24. 24.
    Sim JH, Park YL, Lee JS, Lee SY, Choi WB, Kim HJ, Lee JH (2014) Treatment of melasma by low-fluence 1064 nm Q-switched Nd:YAG laser. J Dermatol Treat 25(3):212–217.  https://doi.org/10.3109/09546634.2012.735639 CrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Plastic SurgeryJiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of TCMNanjingChina
  2. 2.Cardiovascular Medicine DepartmentSuqian Hospital of TCMSuqianPeople’s Republic of China
  3. 3.General Surgery DepartmentNanjing Pukou District Hospital of TCMNanjingPeople’s Republic of China
  4. 4.College of Basic MedicineNanjing University of Chinese MedicineNanjingChina

Personalised recommendations