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Low-intensity LED therapy (658 nm) on burn healing: a series of cases


The objective of this study was to evaluate the effects of LED on burns healing. Five patients with skin burns were submitted to photobiomodulation by LED, GaAsIP diode, (λ 658 nm) with 40 mW, 7 J/cm2 on every other day. Biopsies of burned skin were performed and the healing process was photographed. Patients with bilateral burns were used as self-control, having one limb being irradiated and the contralateral limb irradiated with placebo. The burns treated with LED showed higher epithelization, with keratinocytes and fibroblasts proliferation, increased collagen synthesis, decreased pain, and pruritus. In conclusion, there was a faster clinical improvement in the irradiated limbs.

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Correspondence to Rauirys Alencar de Oliveira.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The local research ethics committee has approved the research (CAAE 60245416.1.0000.5209) and it was registered at the Brazilian Clinical Trial Registry and the International Clinical Trials Registry Platform of the World Health Organization under Trials RBR 3mbdx6 and Universal Trial Number U1111-1186-6131, respectively.

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Informed consent was obtained from all individual participants included in the study.

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de Oliveira, R.A., Boson, L.L.B., Portela, S.M.M. et al. Low-intensity LED therapy (658 nm) on burn healing: a series of cases. Lasers Med Sci 33, 729–735 (2018).

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  • Low-intensity LED therapy
  • Burns
  • Wound healing