Lasers in Medical Science

, Volume 32, Issue 5, pp 1207–1211 | Cite as

Efficacy of Nd:YAG laser therapy for the treatment of verrucae: a literature review

  • Vincent M. HsuEmail author
  • Adam S. Aldahan
  • John P. Tsatalis
  • Marina Perper
  • Keyvan Nouri
Review Article


Verrucae are benign epithelial proliferations, characteristically 1–20 mm in diameter, caused by human papilloma virus (HPV) infection occurring on the skin and mucosa (Photomed Laser Surg 33(6):338-42, 2015; Lasers Med Sci 29(3):1111-6, 2014). Prevalence of verrucae is 5–20% in children and young adults with peak incidence reported during teenage years (Lasers Med Sci 29(3):1111-6, 2014; J Am Acad Dermatol 22(4):547-66, 1990; J Korean Med Sci 24(5):889-93, 2009). Patients often express significant displeasure with quality of life due to this cosmetic insecurity, as well as functional problems and physical discomfort when they occur on palms of hands and soles of feet. Traditional therapeutic options for warts, such as topical salicyclic acid, topical imiquimod, bleomycin injections, cryotherapy, surgical excision, and electrocautery, have proven somewhat effective but often lead to high recurrence rates or scarring (Photomed Laser Surg 33(6):338-42, 2015). Laser therapy offers an alternative solution by employing selective tissue destruction with minimal risks. We performed a broad literature search in PubMed to obtain all available published articles that studied the treatment of verrucae on the skin with 1064-nm neodymium-doped yttrium aluminum garnet laser. This laser is specifically suited for verruca treatment due to its deeply penetrating 1064-nm wavelength and relatively low risk of pigmentation changes in dark skin types (Photomed Laser Surg 33(6):338-42, 2015). Laser therapy is effective in the treatment of verrucae and has enabled clinicians to provide direct, targeted treatment of warts.


Nd:YAG Lasers LP-Nd:YAG Verruca Warts 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Full disclosure

Vincent M. Hsu had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and Design: Hsu, Aldahan, Tsatalis, Perper, and Nouri. Acquisition, analysis and interpretation of data: Hsu, Aldahan, Tsatalis, Perper and Nouri. Drafting of the manuscript: Hsu, Aldahan, Tsatalis, Perper, and Nouri. Critical revision of the manuscript for important intellectual content: Hsu, Aldahan, Tsatalis, Perper, and Nouri. Statistical analysis: N/A. Funding sources: N/A. Administrative, technical or material support: Hsu, Aldahan, Tsatalis, Perper, and Nouri. Study supervision: Nouri.


  1. 1.
    Bingol UA, Comert A, Cinar C (2015) The overlapped triple circle pulse technique with Nd:YAG laser for refractory hand warts. Photomed Laser Surg 33(6):338–342CrossRefPubMedGoogle Scholar
  2. 2.
    El-Mohamady Ael S, Mearag I, El-Khalawany M, Elshahed A, Shokeir H, Mahmoud A (2014) Pulsed dye laser versus Nd:YAG laser in the treatment of plantar warts: a comparative study. Lasers Med Sci 29(3):1111–1116CrossRefGoogle Scholar
  3. 3.
    Cobb MW (1990) Human papillomavirus infection. J Am Acad Dermatol 22(4):547–566CrossRefPubMedGoogle Scholar
  4. 4.
    Han TY, Lee JH, Lee CK, Ahn JY, Seo SJ, Hong CK (2009) Long-pulsed Nd:YAG laser treatment of warts: report on a series of 369 cases. J Korean Med Sci 24(5):889–893CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Cardoso JC, Calonje E (2011) Cutaneous manifestations of human papillomaviruses: a review. Acta dermatovenerologica Alpina, Pannonica, et Adriatica 20(3):145–154PubMedGoogle Scholar
  6. 6.
    Severson J, Evans TY, Lee P, Chan T, Arany I, Tyring SK (2001) Human papillomavirus infections: epidemiology, pathogenesis, and therapy. Journal of cutaneous medicine and surgery 5(1):43–60PubMedGoogle Scholar
  7. 7.
    Basu P, Banerjee D, Singh P, Bhattacharya C, Biswas J (2013) Efficacy and safety of human papillomavirus vaccine for primary prevention of cervical cancer: a review of evidence from phase III trials and national programs. South Asian Journal of Cancer 2(4):187–192CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Di Mario S, Basevi V, Lopalco PL, Balduzzi S, D'Amico R, Magrini N (2015) Are the two human papillomavirus vaccines really similar? A systematic review of available evidence: efficacy of the two vaccines against HPV. J Immunol Res 2015:435141CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Gibbs S, Harvey I, Sterling J, Stark R (2002) Local treatments for cutaneous warts: systematic review. BMJ 325(7362):461CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Ahn CS, Huang WW (2014) Imiquimod in the treatment of cutaneous warts: an evidence-based review. Am J Clin Dermatol 15(5):387–399CrossRefPubMedGoogle Scholar
  11. 11.
    Lewis TG, Nydorf ED (2006) Intralesional bleomycin for warts: a review. Journal of drugs in dermatology : JDD 5(6):499–504PubMedGoogle Scholar
  12. 12.
    Smith EA, Patel SB, Whiteley MS (2015) Evaluating the success of Nd: YAG laser ablation in the treatment of recalcitrant verruca plantaris and a cautionary note about local anaesthesia on the plantar aspect of the foot. J Eur Acad Dermatol Venereol 29(3):463–467CrossRefPubMedGoogle Scholar
  13. 13.
    Kimura U, Takeuchi K, Kinoshita A, Takamori K, Suga Y (2014) Long-pulsed 1064-nm neodymium:yttrium-aluminum-garnet laser treatment for refractory warts on hands and feet. J Dermatol 41(3):252–257CrossRefPubMedGoogle Scholar
  14. 14.
    Zaak D, Hofstetter A, Frimberger D, Schneede P (2003) Recurrence of condylomata acuminata of the urethra after conventional and fluorescence-controlled Nd:YAG laser treatment. Urology 61(5):1011–1015CrossRefPubMedGoogle Scholar
  15. 15.
    El-Tonsy MH, Anbar TE, El-Domyati M, Barakat M (1999) Density of viral particles in pre and post Nd: YAG laser hyperthermia therapy and cryotherapy in plantar warts. Int J Dermatol 38(5):393–398CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag London 2017

Authors and Affiliations

  • Vincent M. Hsu
    • 1
    Email author
  • Adam S. Aldahan
    • 1
  • John P. Tsatalis
    • 1
  • Marina Perper
    • 1
  • Keyvan Nouri
    • 1
  1. 1.Department of Dermatology and Cutaneous SurgeryUniversity of Miami Miller School of MedicineMiamiUSA

Personalised recommendations