Lasers in Medical Science

, Volume 30, Issue 1, pp 295–301 | Cite as

Effects of far-infrared radiation on heart rate variability and central manifestations in healthy subjects: a resting-fMRI study

  • Yii-Jeng Lin
  • Yen-Ying Kung
  • Wen-Jui Kuo
  • David M. Niddam
  • Chou-Ming Cheng
  • Chih-Che Chou
  • Tzu-Chen Yeh
  • Jen-Chuen Hsieh
  • Jen-Hwey Chiu
Original Article

Abstract

The aim of this study was to investigate the autonomic responses and central manifestations by peripheral FIR stimulation. Ten subjects (mean ± SD age 26.2 ± 3.52 years) received FIR stimulation at left median nerve territory for 40 min. Electrocardiograph was continuously recorded and heart rate variability (HRV) were analyzed. By using a 3 T-MRI scanner, three sessions of resting-state functional magnetic resonance images (fMRI) were acquired, namely, before (baseline-FIR), immediately after (IA-FIR) and 15 min after FIR was turned off (Post-FIR). The fractional amplitude of low-frequency (0.01-0.08 Hz) fluctuation (fALFF) of each session to evaluate the intensity of resting-brain activity in each session was analyzed. Our results showed that FIR stimulation induced significant HRV responses such as an increasing trend of nLF and LF/HF ratio, while FIR increased fALFF in right superior front gyrus, middle frontal gyrus and decreased the resting brain activity at fusiform gyrus, extrastriae cortex, inferior temporal gyrus and middle temporal gyrus, especially 15 min after FIR was turned off. We conclude that the central manifestation and the autonomic responses are prominent during and after FIR stimulation, which provide important mechanistic explanation on human disorder treated by such energy medicine.

Keywords

Far-infrared radiation Heart rate variability Resting state network fMRI 

Abbreviations

FIR

Far-infrared radiation

HRV

Heart rate variability

fMRI

Functional magnetic resonance imaging

fALFF

Fractional amplitude of low-frequency fluctuation

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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  • Yii-Jeng Lin
    • 1
  • Yen-Ying Kung
    • 2
  • Wen-Jui Kuo
    • 3
    • 4
  • David M. Niddam
    • 4
    • 5
  • Chou-Ming Cheng
    • 4
  • Chih-Che Chou
    • 5
  • Tzu-Chen Yeh
    • 4
    • 5
  • Jen-Chuen Hsieh
    • 4
    • 5
    • 6
    • 7
  • Jen-Hwey Chiu
    • 1
    • 8
  1. 1.Institute of Traditional Medicine, School of MedicineNational Yang-Ming UniversityTaipeiRepublic of China
  2. 2.Research Center for Traditional MedicineTaipei Veterans General HospitalTaiwanRepublic of China
  3. 3.Institute of Neuroscience, School of MedicineNational Yang-Ming UniversityTaiwanRepublic of China
  4. 4.Laboratory of Integrated Brain Research, Department of Medical Research and EducationTaipei Veterans General HospitalTaiwanRepublic of China
  5. 5.Institute of Brain Science, School of MedicineNational Yang-Ming, UniversityTaiwanRepublic of China
  6. 6.Brain Research CenterNational Yang-Ming UniversityTaiwanRepublic of China
  7. 7.Institute of Brain ScienceNational Yang-Ming UniversityTaiwanRepublic of China
  8. 8.Division of General SurgeryTaipei Veterans General HospitalTaiwanRepublic of China

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