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Lasers in Medical Science

, Volume 30, Issue 1, pp 117–126 | Cite as

Effect of low-level laser therapy on inflammatory mediator release during chemotherapy-induced oral mucositis: a randomized preliminary study

  • Geisa Badauy Lauria Silva
  • Nancy Tomoko Sacono
  • Angélica Ferreira Othon-Leite
  • Elismauro Francisco Mendonça
  • Adriano Moraes Arantes
  • César Bariani
  • Luciana Garcia Lobo Duarte
  • Mauro Henrique Nogueira Abreu
  • Celso Martins Queiroz-Júnior
  • Tarcília Aparecida Silva
  • Aline Carvalho BatistaEmail author
Original Article

Abstract

Patients undergoing hematopoietic stem cell transplantation (HSCT) are submitted to a conditioning regimen of high-dose chemotherapy, with or without radiation therapy, which usually results in oral ulcerations and mucosal barrier breakdown. Oral mucositis (OM) is a common and debilitating toxicity side effect of autologous and allogeneic HSCT. The aim of this study was to evaluate the effect of low-level laser therapy (LLLT) on the severity of OM and inflammatory mediator (TNF-α, IL-6, IL-1β, IL-10, TGF-β, metalloproteinases, and growth factors) levels in saliva and blood of HSCT patients. Thirty patients were randomly assigned to two groups: control (n = 15) and laser (n = 15). LLLT was applied from the first day of the conditioning regimen until day 7 post-HSCT (D + 7). Saliva and blood were collected from patients on admission (AD), D-1, D + 3, D + 7, and on marrow engraftment day (ME). Clinical results showed less severe OM in the laser group (p < 0.05). The LLLT group showed increased matrix metalloproteinase 2 (MMP-2) levels in saliva on D + 7 (p = 0.04). Significant differences were also observed for IL-10 on D + 7 and on ME in blood plasma, when compared to the control group (p < 0.05). No significant differences were seen in saliva or blood for the other inflammatory mediators investigated. LLLT was clinically effective in reducing the severity of chemotherapy-induced OM in HSCT patients, and its mechanism of action does not seem to be completely linked to the modulation of pro- or anti-inflammatory cytokines, growth factors or matrix metalloproteinases.

Keywords

Mucositis Stomatitis Cancer chemotherapy protocol Hematopoietic stem cell transplant Laser therapy Cytokines 

Notes

Acknowledgments

This study was sponsored by grants from the Foundation for Research Support in the State of Goiás (FAPEG—Grant 2010102670007) and the National Council for Scientific and Technological Development (CNPq—Grant 479587/2010-8). The authors wish to thank Araújo Jorge Hospital, Goiás Cancer Combat Association, Goiânia, Brazil.

Conflict of interest

None declared.

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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  • Geisa Badauy Lauria Silva
    • 1
    • 2
  • Nancy Tomoko Sacono
    • 2
  • Angélica Ferreira Othon-Leite
    • 2
  • Elismauro Francisco Mendonça
    • 2
  • Adriano Moraes Arantes
    • 1
  • César Bariani
    • 1
  • Luciana Garcia Lobo Duarte
    • 1
  • Mauro Henrique Nogueira Abreu
    • 3
  • Celso Martins Queiroz-Júnior
    • 4
  • Tarcília Aparecida Silva
    • 4
  • Aline Carvalho Batista
    • 2
    Email author
  1. 1.Hematopoietic Stem Cell Transplant Unit, Araújo Jorge HospitalAssociação de Combate ao Câncer de GoiásGoiâniaBrazil
  2. 2.Department of Stomatology (Oral Pathology), Dental SchoolFederal University of GoiásGoiâniaBrazil
  3. 3.Department of Preventive and Social Dentistry, Dental SchoolFederal University of Minas GeraisBelo HorizonteBrazil
  4. 4.Department of Oral Surgery and Pathology, Dental SchoolFederal University of Minas GeraisBelo HorizonteBrazil

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