Lasers in Medical Science

, Volume 29, Issue 4, pp 1371–1376 | Cite as

High-intensity versus low-level laser therapy in the treatment of patients with knee osteoarthritis: a randomized controlled trial

  • Abdullah Raddah Kheshie
  • Mohamed Salaheldien Mohamed Alayat
  • Mohamed Mohamed Ebrahim Ali
Original Article


The aim of this randomized controlled study was to compare the effects of low-level laser therapy (LLLT) and high-intensity laser therapy (HILT) on pain relief and functional improvement in patients with knee osteoarthritis (KOA). A total of 53 male patients participated in this study, with a mean (SD) age of 54.6 (8.49) years. Patients were randomly assigned into three groups and treated with HILT and exercise (HILT + EX), LLLT and exercise (LLLT + EX), and placebo laser plus exercise (PL + EX) in groups 1, 2, and 3, respectively. The outcomes measured were pain level measured by visual analog scale (VAS) and knee function measured by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Statistical analyses were performed to compare the differences between baseline and posttreatment measurements. The level of statistical significance was set as P < 0.05. The result showed that HILT and LLLT combined with exercise were effective treatment modalities in decreasing the VAS and WOMAC scores after 6 weeks of treatment. HILT combined with exercises was more effective than LLLT combined with exercises, and both treatment modalities were better than exercises alone in the treatment of patients with KOA.


High-intensity laser therapy Low-level laser therapy Knee osteoarthritis 



The authors would like to thank the Institute of Scientific Research and Revival of Islamic Heritage at Umm Al-Qura University (project # 43209019) for the financial support. The authors express their appreciation to all subjects who participated in this study with all content and cooperation and give special thanks to their colleagues at the Department of Physical Therapy, Faculty of Applied Medical Science, Umm AL-Qura University, Saudi Arabia.


This research received a grant from the Institute of Scientific Research and Revival of Islamic Heritage at Umm Al-Qura University, Makkah, Saudi Arabia.

Conflict of interest



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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  • Abdullah Raddah Kheshie
    • 1
  • Mohamed Salaheldien Mohamed Alayat
    • 2
  • Mohamed Mohamed Ebrahim Ali
    • 2
  1. 1.Department of Anatomy, Faculty of MedicineUmm Al-Qura UniversityMeccaSaudi Arabia
  2. 2.Department of Physical Therapy, Faculty of Applied Medical SciencesUmm Al-Qura UniversityMeccaSaudi Arabia

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