Lasers in Medical Science

, Volume 30, Issue 2, pp 925–939 | Cite as

Effect of phototherapy (low-level laser therapy and light-emitting diode therapy) on exercise performance and markers of exercise recovery: a systematic review with meta-analysis

  • Ernesto Cesar Pinto Leal-JuniorEmail author
  • Adriane Aver Vanin
  • Eduardo Foschini Miranda
  • Paulo de Tarso Camillo de Carvalho
  • Simone Dal Corso
  • Jan Magnus Bjordal
Review Article


Recent studies have explored if phototherapy with low-level laser therapy (LLLT) or narrow-band light-emitting diode therapy (LEDT) can modulate activity-induced skeletal muscle fatigue or subsequently protect against muscle injury. We performed a systematic review with meta-analysis to investigate the effects of phototherapy applied before, during and after exercises. A literature search was performed in Pubmed/Medline database for randomized controlled trials (RCTs) published from 2000 through 2012. Trial quality was assessed with the ten-item PEDro scale. Main outcome measures were selected as: number of repetitions and time until exhaustion for muscle performance, and creatine kinase (CK) activity to evaluate risk for exercise-induced muscle damage. The literature search resulted in 16 RCTs, and three articles were excluded due to poor quality assessment scores. From 13 RCTs with acceptable methodological quality (≥6 of 10 items), 12 RCTs irradiated phototherapy before exercise, and 10 RCTs reported significant improvement for the main outcome measures related to performance. The time until exhaustion increased significantly compared to placebo by 4.12 s (95 % CI 1.21–7.02, p < 0.005) and the number of repetitions increased by 5.47 (95 % CI 2.35–8.59, p < 0.0006) after phototherapy. Heterogeneity in trial design and results precluded meta-analyses for biochemical markers, but a quantitative analysis showed positive results in 13 out of 16 comparisons. The most significant and consistent results were found with red or infrared wavelengths and phototherapy application before exercises, power outputs between 50 and 200 mW and doses of 5 and 6 J per point (spot). We conclude that phototherapy (with lasers and LEDs) improves muscular performance and accelerate recovery mainly when applied before exercise.


Low-level laser therapy Light-emitting diode therapy Exercise performance Exercise recovery Sports 


Contributorship statement

ECPLJ participated in the literature search, development of inclusion and exclusion criteria, selection of trials for inclusion in the analysis, methodological assessment, data extraction and interpretation, writing of the report, and supervised writing of the report as a whole. AAV and EFM participated in the selection of trials for inclusion in the analysis, methodological assessment of RCTs, and data analysis. SDC and PTCC participated in data interpretation and analysis and critically reviewed the report. JMB participated in development of inclusion and exclusion criteria, data analysis and interpretation, writing of the results section of the report, and supervised writing of the report as a whole. All authors read and approved the final manuscript.


Professor Ernesto Cesar Pinto Leal-Junior would like to thank FAPESP grant number 2010/52404-0. Adriane Aver Vanin would like to thank FAPESP for the Master’s degree scholarship (number 2012/02442-8).

Conflict of interest

Professor Ernesto Cesar Pinto Leal-Junior receives research support from Multi Radiance Medical (Solon, OH, USA), a laser device manufacturer. Multi-Radiance Medical had no role in the planning of this study. They had no influence on study design, data collection and analysis, decision to publish, or preparation of the manuscript. The other authors declare that they have no conflict of interests.


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Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  • Ernesto Cesar Pinto Leal-Junior
    • 1
    • 2
    Email author
  • Adriane Aver Vanin
    • 1
  • Eduardo Foschini Miranda
    • 1
  • Paulo de Tarso Camillo de Carvalho
    • 1
    • 2
  • Simone Dal Corso
    • 1
  • Jan Magnus Bjordal
    • 3
  1. 1.Postgraduate Program in Rehabilitation SciencesUniversidade Nove de JulhoSão PauloBrazil
  2. 2.Postgraduate Program in Biophotonics Applied to Health SciencesUniversidade Nove de JulhoSão PauloBrazil
  3. 3.Physiotherapy Research Group, Faculty of Medicine and DentistryUniversity of BergenBergenNorway

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