Acute effects of light emitting diodes therapy (LEDT) in muscle function during isometric exercise in patients with chronic obstructive pulmonary disease: preliminary results of a randomized controlled trial
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Patients with chronic obstructive pulmonary disease (COPD) are susceptible to early muscle fatigue. Light-emitting diodes therapy (LEDT) has been used to minimize muscle fatigue in athletes and healthy subjects. The aim of this study is to investigate the acute effects of LEDT on muscle fatigue and perception of effort in patients with COPD during isometric endurance test of the quadriceps femoris (QF). Ten patients (VEF1 50 ± 13 % of predicted) underwent a single LEDT and sham application, 48 h apart, in a randomized crossover design. The LEDT and sham were applied in three localized areas of the QF (rectus femoris, vastus lateralis, and vastus medialis). Before and after exposure to LEDT and sham, the patients performed an isometric endurance test (60 % of the maximum voluntary isometric contraction), until the limit of tolerance concomitant to surface electromyography recording (median frequency as mean outcome). The slope obtained from linear regression analysis of the median frequency (MF) over endurance time was also used as an endurance index. Endurance time increased significantly after exposure to LEDT (from 26 ± 2 to 53 ± 5 s) as compared to sham (from 23 ± 3 to 30 ± 4 s) (F = 64, P = 0.0001). A greater decline in MF was observed during isometric endurance test after sham, compared to LEDT (F = 14.6, P = 0.004). The slope of the MF over time was lower post-LEDT compared to post-sham (−0.7 ± 0.3 vs. −1.5 ± 0.8; P = 0.004). The dyspnea score corrected for endurance time was lower post-LEDT (P = 0.008) but similar for fatigue both post-LEDT and post-sham. A single application of LEDT minimizes muscle fatigue and increases isometric endurance time.
KeywordsCOPD LED therapy Muscle fatigue and phototherapy
Conflict of interest
The authors declare that they have no competing interests and no financial competing interests.
- 1.Global Initiative for Chronic Obstructive Lung Disease. Global strategy of the diagnosis, management and prevention of chronic obstructive pulmonary disease updated. National Institutes of Health and National Heart, Lung and Blood Institute. Eur Respir J 2003; 22: 1–95.Google Scholar
- 2.American Thoracic Society and European Respiratory Society (1999) Skeletal muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 159(4 Pt 2):S1–S40Google Scholar
- 8.Mester E, Szende B, Tota JG (1967) Effect of laser on hair growth of mice. Kiserl Orvostud 19:628–631Google Scholar
- 10.Leal Junior EC, Lopes-Martins RA, Rossi RP, De Marchi T, Baroni BM, de Godoi V, Marcos RL, Ramos L, Bjordal JM (2009) Effect of cluster multi-diode light emitting diode therapy (LEDT) on exercise-induced skeletal muscle fatigue and skeletal muscle recovery in humans. Lasers Surg Med 41(8):572–577PubMedCrossRefGoogle Scholar
- 11.Leal Junior EC, de Godoi V, Mancalossi JL, Rossi RP, De Marchi T, Parente M, Grosselli D, Generosi RA, Basso M, Frigo L, Tomazoni SS, Bjordal JM, Lopes-Martins RA (2011) Comparison between cold water immersion therapy (CWIT) and light emitting diode therapy (LEDT) in short-term skeletal muscle recovery after high-intensity exercise in athletes—preliminary results. Lasers Med Sci 26(4):493–501PubMedCentralPubMedCrossRefGoogle Scholar
- 12.Leal Junior EC, Lopes-Martins RA, Baroni BM, De Marchi T, Rossi RP, Grosselli D, Generosi RA, de Godoi V, Basso M, Mancalossi JL, Bjordal JM (2009) Comparison between single-diode low-level laser therapy (LLLT) and LEDT multi-diode (cluster) therapy (LEDT) applications before high-intensity exercise. Photomed Laser Surg 27(4):617–623PubMedCrossRefGoogle Scholar
- 14.de Almeida P, Lopes-Martins RA, De Marchi T, Tomazoni SS, Albertini R, Corrêa JC, Rossi RP, Machado GP, da Silva DP, Bjordal JM, Leal Junior EC (2012) Red (660 nm) and infrared (830 nm) low-level laser therapy in skeletal muscle fatigue in humans: what is better? Lasers Med Sci 27(2):453–458PubMedCentralPubMedCrossRefGoogle Scholar
- 17.Leal Junior EC, Lopes-Martins RA, Frigo L, De Marchi T, Rossi RP, de Godoi V, Tomazoni SS, Silva DP, Basso M, Filho PL, de Valls CF, Iversen VV, Bjordal JM (2010) Effects of low-level laser therapy (LLLT) in the development of exercise-induced skeletal muscle fatigue and changes in biochemical markers related to post-exercise recovery. J Orthop Sports Phys Ther 40(8):524–532PubMedCrossRefGoogle Scholar
- 30.Queiroz LS, Wollmann DER, Nicolau RA, Pacheco MTT (2008) Effect of lead irradiation on microcirculation of auricular mouse. Rev Assoc Paul Cir Dent 62:138–142Google Scholar