Proinflammatory cytokine levels in saliva in patients with burning mouth syndrome before and after treatment with low-level laser therapy
- 636 Downloads
The aim of this study was to determine the levels of proinflammatory tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) cytokines in whole unstimulated saliva in subjects with burning mouth syndrome (BMS) before and after treatment with low-level laser therapy (LLLT). BMS is characterized by a continuous, painful burning sensation in a clinically normal-appearing oral mucosa. A sample consisting of 40 consecutive subjects was selected on a voluntary basis from the pool of patients who presented for diagnosis and treatment of BMS at the Oral Medicine Unit of the Faculty of Medicine of the University of Rijeka. For determination of salivary levels of TNF-α and IL-6, ELISA (Sigma Immunochemicals, St. Louis, MO, USA) was performed to determine the salivary levels of TNF-α and IL-6. After 4 weeks of LLLT, the salivary levels of TNF-α and IL-6 in the experimental group decreased significantly (p < 0.001). There was no significant difference in the experimental group regarding visual analogue scale.
KeywordsBurning mouth Laser Cytokine
This research was supported by a grant from the Ministry of Science and Technology (062-0650444-0442), Republic of Croatia.
- 1.Lamey PJ, Lamb AB (1988) Prospective study of etiological factors in burning mouth syndrome. Br Med J 296:1234–1236Google Scholar
- 10.Antunes HS, de Azevedo AM, da Silva Bouzas LF, Adão CA, Pinheiro CT, Mayhe R, Pinheiro LH, Azevedo R, D'Aiuto de Matos V, Rodrigues PC, Small IA, Zangaro RA, Ferreira CG (2006) Low-power laser in the prevention of induced oral mucositis in bone marrow transplantation patients: a randomized trial. Blood 109:2250–2255PubMedCrossRefGoogle Scholar
- 11.Simčić D, Pezelj-Ribarić S, Grzić R, Horvat J, Brumini G, Muhvić-Urek M (2006) Detection of salivary interleukin 2 and interleukin 6 in patients with burning mouth syndrome. Mediat Inflamm 1:54632Google Scholar
- 12.Chen CP, Hertzberg M, Jiang Y, Graves DT (1999) Interleukin-1 and tumor necrosis factor receptor signaling is not required for bacteria induced osteoclastogenesis and bone loss but is essential for protecting the host from a mixed anaerobic infection. Am J Pathol 155:2145–2152PubMedCrossRefGoogle Scholar
- 20.Antunes HS, Ferreira EM, de Matos VD, Pinheiro CT, Ferreira CG (2008) The impact of low power laser in the treatment of conditioning-induced oral mucositis: a report of 11 clinical cases and their review. Med Oral Patol Oral Cirug Bucal 13:189–192Google Scholar