Lasers in Medical Science

, Volume 28, Issue 1, pp 297–301 | Cite as

Proinflammatory cytokine levels in saliva in patients with burning mouth syndrome before and after treatment with low-level laser therapy

  • Sonja Pezelj-RibarićEmail author
  • Lumnije Kqiku
  • Gordana Brumini
  • Miranda Muhvić Urek
  • Robert Antonić
  • Davor Kuiš
  • Irena Glažar
  • Peter Städtler
Original Article


The aim of this study was to determine the levels of proinflammatory tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) cytokines in whole unstimulated saliva in subjects with burning mouth syndrome (BMS) before and after treatment with low-level laser therapy (LLLT). BMS is characterized by a continuous, painful burning sensation in a clinically normal-appearing oral mucosa. A sample consisting of 40 consecutive subjects was selected on a voluntary basis from the pool of patients who presented for diagnosis and treatment of BMS at the Oral Medicine Unit of the Faculty of Medicine of the University of Rijeka. For determination of salivary levels of TNF-α and IL-6, ELISA (Sigma Immunochemicals, St. Louis, MO, USA) was performed to determine the salivary levels of TNF-α and IL-6. After 4 weeks of LLLT, the salivary levels of TNF-α and IL-6 in the experimental group decreased significantly (p < 0.001). There was no significant difference in the experimental group regarding visual analogue scale.


Burning mouth Laser Cytokine 



This research was supported by a grant from the Ministry of Science and Technology (062-0650444-0442), Republic of Croatia.


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Copyright information

© Springer-Verlag London Ltd 2012

Authors and Affiliations

  • Sonja Pezelj-Ribarić
    • 1
    Email author
  • Lumnije Kqiku
    • 2
  • Gordana Brumini
    • 3
  • Miranda Muhvić Urek
    • 1
  • Robert Antonić
    • 4
  • Davor Kuiš
    • 1
  • Irena Glažar
    • 1
  • Peter Städtler
    • 2
  1. 1.Department of Oral Medicine and Periodontology, School of Dentistry, Faculty of MedicineUniversity of RijekaRijekaCroatia
  2. 2.Department of Preventive and Operative Dentistry, Endodontics, Pedodontics, and Minimally Invasive DentistryUniversity Dental ClinicGrazAustria
  3. 3.Department of Informatics, Faculty of MedicineUniversity of RijekaRijekaCroatia
  4. 4.Department of Prosthodontics, School of Dentistry, Faculty of MedicineUniversity of RijekaRijekaCroatia

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