Lasers in Medical Science

, Volume 27, Issue 3, pp 629–635

Low-level laser therapy improves repair following complete resection of the sciatic nerve in rats

  • Carla Christina Medalha
  • Giuliana Castro Di Gangi
  • Caroline Bublitz Barbosa
  • Marcela Fernandes
  • Odair Aguiar
  • Flávio Faloppa
  • Vilnei Mattioli Leite
  • Ana Claudia Muniz Renno
Original Article


The aim of this study is to analyze the effects of low-level laser therapy (LLLT) on the regeneration of the sciatic nerve in rats following a complete nerve resection. Male Wistar rats were divided into a control injury group, injury groups irradiated with a 660-nm laser at 10 or 50 J/cm2, and injury groups irradiated with an 808-nm laser at 10 or 50 J/cm2. Treatment began 24 h following nerve resection and continued for 15 days. Using the sciatic functional index (SFI), we show that the injured animals treated with 660 nm at 10 and 50 J/cm2 had better SFI values compared with the control injury and the 808-nm groups. Animals irradiated with the 808-nm laser at 50 J/cm2 show higher values for fiber density than do control animals. In addition, axon and fiber diameters were larger in animals irradiated with 660 nm at 50 J/cm2 compared to the control group. These findings indicate that 660-nm LLLT is able to provide functional gait recovery and leads to increases in fiber diameter following sciatic nerve resection.


Laser therapy Nerve regeneration Sciatic nerve 


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Copyright information

© Springer-Verlag London Ltd 2011

Authors and Affiliations

  • Carla Christina Medalha
    • 1
  • Giuliana Castro Di Gangi
    • 1
  • Caroline Bublitz Barbosa
    • 1
  • Marcela Fernandes
    • 2
  • Odair Aguiar
    • 1
  • Flávio Faloppa
    • 2
  • Vilnei Mattioli Leite
    • 2
  • Ana Claudia Muniz Renno
    • 1
  1. 1.Department of BioscienceFederal University of São Paulo (UNIFESP)SantosBrazil
  2. 2.Department of Orthopedics and TraumatologyFederal University of São Paulo (UNIFESP)São PauloBrazil

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