Lasers in Medical Science

, Volume 23, Issue 4, pp 361–367 | Cite as

ALA and Photofrin® Fluorescence-guided resection and repetitive PDT in glioblastoma multiforme: a single centre Phase III randomised controlled trial

  • M. Sam EljamelEmail author
  • Carol Goodman
  • Harry Moseley
Original article


Glioblastoma multiforme (GBM) carries dismal prognosis and cannot be eradicated surgically because of its wide brain invasion. The objective of this prospective randomised controlled trial was to evaluate ALA and Photofrin® fluorescence-guided resection (FGR) and repetitive photodynamic therapy (PDT) in GBM. We recruited 27 patients; 13 were in the study group and 14 were in the control group. The mean survival of the study group was 52.8 weeks compared to 24.6 weeks in the control group (p < 0.01). The study group gained on average 20 points on the Karnofsky performance score (p < 0.05). There were no differences in complications or hospital stay between the two groups. The mean time to tumour progression was 8.6 months in the study group compared to 4.8 months in the control group (p < 0.05). Therefore, ALA and Photofrin® fluorescence-guided resection and repetitive PDT offered a worthwhile survival advantage without added risk to patients with GBM. A multicentre randomized controlled trial is warranted to confirm these results.


Laser Glioblastoma Photodiagnosis Photoirradiation Spectroscopy Surgery 



We are grateful to the Laser technicians, nurses, other therapists and doctors, who assisted in delivering care and therapy to our patients.

This study was funded by Barbara Stewart Cancer Trust, a charitable organisation dedicated for funding the advancement of photodynamic techniques in cancer treatment.


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Copyright information

© Springer-Verlag London Limited 2007

Authors and Affiliations

  • M. Sam Eljamel
    • 1
    • 2
    • 3
    Email author
  • Carol Goodman
    • 1
    • 2
    • 3
  • Harry Moseley
    • 1
    • 2
    • 3
  1. 1.The Scottish Photodynamic Therapy CentreDundeeUK
  2. 2.NHS Tayside and the University of DundeeDundeeUK
  3. 3.Department of NeurosurgeryNinewells Hospital and Medical SchoolDundeeUK

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